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http://hdl.handle.net/2445/101708
Title: | Magnetite-Amyloid-β deteriorates activity and functional organization in an in vitro model for Alzheimer's disease |
Author: | Teller Amado, Sara Tahirbegi, Islam Bogachan Mir Llorente, Mònica Samitier i Martí, Josep Soriano i Fradera, Jordi |
Keywords: | Malaltia d'Alzheimer Magnetita Amiloïdosi Alzheimer's disease Magnetite Amyloidosis |
Issue Date: | 26-Nov-2015 |
Publisher: | Nature Publishing Group |
Abstract: | The understanding of the key mechanisms behind human brain deterioration in Alzheimer' disease (AD) is a highly active field of research. The most widespread hypothesis considers a cascade of events initiated by amyloid-β peptide fibrils that ultimately lead to the formation of the lethal amyloid plaques. Recent studies have shown that other agents, in particular magnetite, can also play a pivotal role. To shed light on the action of magnetite and amyloid-β in the deterioration of neuronal circuits, we investigated their capacity to alter spontaneous activity patterns in cultured neuronal networks. Using a versatile experimental platform that allows the parallel monitoring of several cultures, the activity in controls was compared with the one in cultures dosed with magnetite, amyloid-β and magnetite-amyloid-β complex. A prominent degradation in spontaneous activity was observed solely when amyloid-β and magnetite acted together. Our work suggests that magnetite nanoparticles have a more prominent role in AD than previously thought, and may bring new insights in the understanding of the damaging action of magnetite-amyloid-β complex. Our experimental system also offers new interesting perspectives to explore key biochemical players in neurological disorders through a controlled, model system manner. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1038/srep17261 |
It is part of: | Scientific Reports, 2015, vol. 5, num. 17261 |
URI: | http://hdl.handle.net/2445/101708 |
Related resource: | http://dx.doi.org/10.1038/srep17261 |
ISSN: | 2045-2322 |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
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