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Title: Highly Enantioselective Iridium-Catalyzed Hydrogenation of Cyclic Enamides
Author: Salomó i Prat, Ernest
Orgué Gassol, Sílvia
Riera i Escalé, Antoni
Verdaguer i Espaulella, Xavier
Keywords: Hidrogenació
Catàlisi asimètrica
Enantioselective catalysis
Issue Date: 17-May-2016
Publisher: Wiley
Abstract: The MaxPHOX-Ir catalyst system provided the highest selectivity ever reported for the redn. of cyclic enamides derived from α- and β-tetralones. This result indicates that iridium catalysts are also proficient in reducing alkenes bearing metal-coordinating groups. In the present system, selectivity was pressure-dependent: in most cases, a decrease in the H2 pressure to 3 bar resulted in an increase in enantioselectivity. Moreover, the process can be carried out in environmentally friendly solvents, such as methanol and Et acetate, with no loss of selectivity.
Note: Reproducció del document publicat a:
It is part of: Angewandte Chemie International Edition, 2016, vol. 55, p. 7988-7992
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ISSN: 0003-3022
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

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