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Title: Supplementary material to Ocaña, J., Sánchez, M.P., Sánchez, A. and Carrasco, J.L. ¿On equivalence and bioequivalence testing¿, SORT, 32(2), 2008
Author: Ocaña i Rebull, Jordi
Sánchez Olavarría, María Pilar
Sànchez, Àlex (Sànchez Pla)
Carrasco Jordan, Josep Lluís
Keywords: Mètodes estadístics
Equivalència terapèutica dels medicaments
Statistical methods
Therapeutic equivalency in drugs
Issue Date: 5-Jun-2008
Abstract: Equivalence testing is the natural approach to many statistical problems. First, its main application, bioequivalence testing, is reviewed. The basic concepts of bioequivalence testing (2×2 crossover designs, TOST, interval inclusion principle, etc.) and its problems (TOST biased character, the carry- over problem, etc.) are considered. Next, equivalence testing is discussed more generally. Some applications and methods are reviewed and the relation of equivalence testing and distance-based inference is highlighted. A new distance-based method to determine whether two gene lists are equivalent in terms of their annotations in the Gene Ontology illustrates these ideas. We end with a general discussion and some suggestions for future research.
Note: Reproducció digital del document original
Appears in Collections:Documents de treball / Informes (Genètica, Microbiologia i Estadística)

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