Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/115969
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hofmann, Natalie E. | - |
dc.contributor.author | Karl, Stephan | - |
dc.contributor.author | Wampfler, Rahel | - |
dc.contributor.author | Kiniboro, Benson | - |
dc.contributor.author | Teliki, Albina | - |
dc.contributor.author | Iga, Jonah | - |
dc.contributor.author | Waltmann, Andreea | - |
dc.contributor.author | Betuela, Inoni | - |
dc.contributor.author | Felger, Ingrid | - |
dc.contributor.author | Robinson, Leanne J. | - |
dc.contributor.author | Mueller, Ivo | - |
dc.date.accessioned | 2017-09-28T11:17:45Z | - |
dc.date.available | 2017-09-28T11:17:45Z | - |
dc.date.issued | 2017-09-01 | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/2445/115969 | - |
dc.description.abstract | The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT02143934. | - |
dc.format.extent | 23 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | eLife Sciences Publications | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.7554/eLife.23708 | - |
dc.relation.ispartof | ELife, 2017, vol. 6, num. , p. e23708 | - |
dc.relation.uri | http://dx.doi.org/10.7554/eLife.23708 | - |
dc.rights | cc by (c) Hofmann et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (ISGlobal) | - |
dc.subject.classification | Malària | - |
dc.subject.classification | Papua Nova Guinea | - |
dc.subject.classification | Plasmodium vivax | - |
dc.subject.other | Malaria | - |
dc.subject.other | Papua New Guinea | - |
dc.subject.other | Plasmodium vivax | - |
dc.title | The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2017-09-27T17:59:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 28862132 | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
hofmann2017_2680.pdf | 2.29 MB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License