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Title: | The complex relationship of exposure to new Plasmodium infections and incidence of clinical malaria in Papua New Guinea |
Author: | Hofmann, Natalie E. Karl, Stephan Wampfler, Rahel Kiniboro, Benson Teliki, Albina Iga, Jonah Waltmann, Andreea Betuela, Inoni Felger, Ingrid Robinson, Leanne J. Mueller, Ivo |
Keywords: | Malària Papua Nova Guinea Plasmodium vivax Malaria Papua New Guinea Plasmodium vivax |
Issue Date: | 1-Sep-2017 |
Publisher: | eLife Sciences Publications |
Abstract: | The molecular force of blood-stage infection (molFOB) is a quantitative surrogate metric for malaria transmission at population level and for exposure at individual level. Relationships between molFOB, parasite prevalence and clinical incidence were assessed in a treatment-to-reinfection cohort, where P.vivax (Pv) hypnozoites were eliminated in half the children by primaquine (PQ). Discounting relapses, children acquired equal numbers of new P. falciparum (Pf) and Pv blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23) resulting in comparable spatial and temporal patterns in incidence and prevalence of infections. Including relapses, Pv-molFOB increased >3 fold (relative to PQ-treated children) showing greater heterogeneity at individual (Pv-molFOB = 0-36) and village levels. Pf- and Pv-molFOB were strongly associated with clinical episode risk. Yearly Pf clinical incidence rate (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower Pf-molFOB. These relationships between molFOB, clinical incidence and parasite prevalence reveal a comparable decline in Pf and Pv transmission that is normally hidden by the high burden of Pv relapses. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov NCT02143934. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.7554/eLife.23708 |
It is part of: | ELife, 2017, vol. 6, num. , p. e23708 |
URI: | http://hdl.handle.net/2445/115969 |
Related resource: | http://dx.doi.org/10.7554/eLife.23708 |
ISSN: | 2050-084X |
Appears in Collections: | Articles publicats en revistes (ISGlobal) |
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