Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/121617
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dc.contributor.authorKaroutzou, Olga-
dc.contributor.authorKwak, Seung-Hwa-
dc.contributor.authorLee, So-Deok-
dc.contributor.authorMartínez-Falguera, Daina-
dc.contributor.authorSureda, Francesc X.-
dc.contributor.authorVázquez Cruz, Santiago-
dc.contributor.authorKim, Yong-Chul-
dc.contributor.authorBarniol-Xicota, Marta-
dc.date.accessioned2018-04-17T12:04:33Z-
dc.date.available2018-04-17T12:04:33Z-
dc.date.issued2018-01-21-
dc.identifier.issn1420-3049-
dc.identifier.urihttp://hdl.handle.net/2445/121617-
dc.description.abstractMulti-target-directed ligands (MTDLs) offer new hope for the treatment of multifactorial complex diseases such as Alzheimer's Disease (AD). Herein, we present compounds aimed at targeting the NMDA and the P2X7 receptors, which embody a different approach to AD therapy. On one hand, we are seeking to delay neurodegeneration targeting the glutamatergic NMDA receptors; on the other hand, we also aim to reduce neuroinflammation, targeting P2X7 receptors. Although the NMDA receptor is a widely recognized therapeutic target in treating AD, the P2X7 receptor remains largely unexplored for this purpose; therefore, the dual inhibitor presented herein¿which is open to further optimization¿represents the first member of a new class of MTDLs.-
dc.format.extent13 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherMDPI-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/molecules23010230-
dc.relation.ispartofMolecules, 2018, vol. 23, num. 230, p. 1-13-
dc.relation.urihttps://doi.org/10.3390/molecules23010230-
dc.rightscc-by (c) Karoutzou, Olga et al., 2018-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)-
dc.subject.classificationMalaltia d'Alzheimer-
dc.subject.classificationReceptors cel·lulars-
dc.subject.classificationNeurociències-
dc.subject.otherAlzheimer's disease-
dc.subject.otherCell receptors-
dc.subject.otherNeurosciences-
dc.titleTowards a Novel Class of Multitarget-Directed Ligands: Dual P2X7-NMDA Receptor Antagonists-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec675726-
dc.date.updated2018-04-17T12:04:33Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid29361735-
Appears in Collections:Articles publicats en revistes (Institut de Biomedicina (IBUB))
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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