Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/126592
Title: | Absence of canonical active chromatin marks in developmentally regulated genes |
Author: | Pérez-Lluch, Sílvia Blanco García, Enrique Tilgner, Hagen Curado, Joao Ruiz Romero, Marina Corominas, Montserrat (Corominas Guiu) Guigó Serra, Roderic |
Keywords: | Expressió gènica Histones Transcripció genètica Gene expression Histones Genetic transcription |
Issue Date: | 17-Aug-2015 |
Publisher: | Nature Publishing Group |
Abstract: | The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications. Conversely, strong chromatin marking is related to transcriptional and post-transcriptional stability, an association that we also observe in mammals. Our results support a model in which chromatin marking is associated with the stable production of RNA, whereas unmarked chromatin would permit rapid gene activation and deactivation during development. In the latter case, regulation by transcription factors would have a comparatively more important regulatory role than chromatin marks. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1038/ng.3381 |
It is part of: | Nature Genetics, 2015, vol. 47, num. 10, p. 1158-1167 |
URI: | http://hdl.handle.net/2445/126592 |
Related resource: | https://doi.org/10.1038/ng.3381 |
ISSN: | 1061-4036 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Publicacions de projectes de recerca finançats per la UE |
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654376.pdf | 2.75 MB | Adobe PDF | View/Open |
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