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2019-01-29

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cc-by-nc-nd (c) Arcos Burgos, Mauricio et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/129262

ADGRL3 (LPHN3) variants predict substance use disorder

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https://doi.org/10.1038/s41398-019-0396-7

Resum

Genetic factors are strongly implicated in the susceptibility to develop externalizing syndromes such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, conduct disorder, and substance use disorder (SUD). Variants in the ADGRL3 (LPHN3) gene predispose to ADHD and predict ADHD severity, disruptive behaviors comorbidity, long-term outcome, and response to treatment. In this study, we investigated whether variants within ADGRL3 are associated with SUD, a disorder that is frequently co-morbid with ADHD. Using family-based, case-control, and longitudinal samples from disparate regions of the world (n = 2698), recruited either for clinical, genetic epidemiological or pharmacogenomic studies of ADHD, we assembled recursive-partitioning frameworks (classification tree analyses) with clinical, demographic, and ADGRL3 genetic information to predict SUD susceptibility. Our results indicate that SUD can be efficiently and robustly predicted in ADHD participants. The genetic models used remained highly efficient in predicting SUD in a large sample of individuals with severe SUD from a psychiatric institution that were not ascertained on the basis of ADHD diagnosis, thus identifying ADGRL3 as a risk gene for SUD. Recursive-partitioning analyses revealed that rs4860437 was the predominant predictive variant. This new methodological approach offers novel insights into higher order predictive interactions and offers a unique opportunity for translational application in the clinical assessment of patients at high risk for SUD.

Matèries

Genètica de la conducta, Drogoaddicció, Trastorns per dèficit d'atenció amb hiperactivitat en els adults, Consum d'alcohol, Genètica humana

Matèries (anglès)

Behavior genetics, Drug addiction, Attention deficit disorder with hyperactivity in adults, Drinking of alcoholic beverages, Human genetics

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

Citació

ARCOS BURGOS, Mauricio, RIBASÉS HARO, Marta, MARTÍNEZ, Ariel f., RAMOS QUIROGA, Josep antoni, SÁNCHEZ MORA, Cristina, RICHARTE, Vanesa, RONCERO, Carlos, CORMAND RIFÀ, Bru, FERNÀNDEZ CASTILLO, Noèlia, CASAS, Miguel, VÉLEZ, Jorge i., LOPERA, Francisco, PINEDA, David a., PALACIO, Juan d., MOLINA, Brooke s. g., BODEN, Margaret t., WALLIS, Deeann, LIDBURY, Brett, PATEL, Hardip, NEWMAN, Saul, EASTEAL, Simon, SWANSON, James, MASTRONARDI, Claudio a., VOLKOW, Nora d., ACOSTA, Maria t., CASTELLANOS, Francisco x., LEON, José de, MUENKE, Maximillian, ACOSTA LÓPEZ, Johan e., MTA Cooperative Group, CERVANTES HENRIQUEZ, Martha l., SÁNCHEZ ROJAS, Manuel g., PUENTES ROZO, Pedro j., MOLINA, Brooke s. g.. ADGRL3 (LPHN3) variants predict substance use disorder. _Translational Psychiatry_. 2019. Vol. 9, núm. 1, pàgs. 42. [consulta: 13 de febrer de 2026]. ISSN: 2158-3188. [Disponible a: https://hdl.handle.net/2445/129262]

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