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http://hdl.handle.net/2445/130327
Title: | Metabotypes of response to bariatric surgery independent of the magnitude of weight loss |
Author: | Palau Rodríguez, Magalí Tulipani, Sara Marco Ramell, Anna Miñarro Alonso, Antonio Jáuregui Pallarés, Olga Sànchez, Àlex (Sànchez Pla) Ramos Molina, Bruno Tinahones, Francisco J. Andrés Lacueva, Ma. Cristina |
Keywords: | Cirurgia de l'obesitat Aprimament Obesitat mòrbida Metabolisme Obesity surgery Weight loss Morbid obesity Metabolism |
Issue Date: | 1-Jun-2018 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Objective Bariatric surgery is considered the most efficient treatment for morbid obesity and its related diseases. However, its role as a metabolic modifier is not well understood. We aimed to determine biosignatures of response to bariatric surgery and elucidate short-term metabolic adaptations. Methods We used a LC- and FIA-ESI-MS/MS approach to quantify acylcarnitines, (lyso)phosphatidylcholines, sphingomyelins, amino acids, biogenic amines and hexoses in serum samples of subjects with morbid obesity (n = 39) before and 1, 3 and 6 months after bariatric surgery. K-means cluster analysis allowed to distinguish metabotypes of response to bariatric surgery. Results For the first time, global metabolic changes following bariatric surgery independent of the baseline health status of the subjects have been revealed. We identify two metabolic phenotypes (metabotypes) at the interval 6 months-baseline after surgery, which presented differences in the levels of compounds of urea metabolism, gluconeogenic precursors and (lyso)phospholipid particles. Clinically, metabotypes were different in terms of the degree of improvement in insulin resistance, cholesterol, low-density lipoproteins and uric acid independent of the magnitude of weight loss. Conclusions This study opens new perspectives and new hypotheses on the metabolic benefits of bariatric surgery and understanding of the biology of obesity and its associated diseases. |
Note: | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0198214 |
It is part of: | PLoS One, 2018, vol. 13, num. 6, p. e0198214 |
URI: | http://hdl.handle.net/2445/130327 |
Related resource: | https://doi.org/10.1371/journal.pone.0198214 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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