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http://hdl.handle.net/2445/145578
Title: | Periodontal treatment on patients with cardiovascular disease: systematic review and meta-analysis |
Author: | Roca Millan, Elisabet González Navarro, Beatriz Sabater Recolons, Ma. del Mar Marí Roig, Antonio Jané Salas, Enric López López, José, 1958- |
Keywords: | Malalties periodontals Malalties cardiovasculars Aterosclerosi Periodontal disease Cardiovascular diseases Atherosclerosis |
Issue Date: | 1-Nov-2018 |
Publisher: | Medicina Oral SL |
Abstract: | Background: atherosclerotic cardiovascular disease is the main cause of mortality in developed countries. It is a chronic and systemic inflammatory disease with a multifactorial etiology. Periodontal disease is one of the many factors that contribute to its development. Objective: to analyze the effects of periodontal treatment on cardiovascular risk parameters in patients with atherosclerotic cardiovascular disease. Methods: a systematic research was conducted in the Pubmed/Medline databases for clinical trials published up to and including the year 2017. Results: ten articles were included for analysis. Periodontal treatment reduced C-reactive protein levels (77.8% of clinical trials), tumor necrosis factor-alpha (66.7%), interleukin-6 (100%) and leukocytes (50%). Fibrinogen levels also improved considerably (66.7%). Effects on lipid parameters were more limited, whereby only oxidized low density lipoprotein and very low density lipoprotein cholesterol decreased significantly. Meta-analysis showed a statistically significant decreased in C-reactive protein and leukocytes values when patients were submitted to non-surgical periodontal treatment in contrast to receiving no treatment at all (mean difference 1.199 mg/L, 95% confidence interval: 1.100-1.299, p<0.001; and mean difference 0,79 g/L, 95% confidence interval: 0.717-0.879, p<0.001, respectively). Conclusions: periodontal treatment has a beneficial effect on some of the biochemical parameters considered to represent cardiovascular risk. Further randomized clinical trials are necessary, with longer follow-up periods including regular periodic monitoring, in order to determine the extent of the impact of periodontal treatment. |
Note: | Podeu consultar la versió en castellà del document a: http://hdl.handle.net/2445/153580 |
Note: | Reproducció del document publicat a: https://doi.org/10.4317/medoral.22725 |
It is part of: | Medicina Oral, Patología Oral y Cirugía Bucal, 2018, vol. 23, num. 6, p. 681-690 |
URI: | http://hdl.handle.net/2445/145578 |
Related resource: | https://doi.org/10.4317/medoral.22725 |
ISSN: | 1698-4447 |
Appears in Collections: | Articles publicats en revistes (Odontoestomatologia) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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683652.pdf | 1.16 MB | Adobe PDF | View/Open |
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