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Title: Periodontal treatment on patients with cardiovascular disease: systematic review and meta-analysis
Author: Roca Millan, Elisabet
González Navarro, Beatriz
Sabater Recolons, Ma. del Mar
Marí Roig, Antonio
Jané Salas, Enric
López López, José, 1958-
Keywords: Malalties periodontals
Malalties cardiovasculars
Periodontal disease
Cardiovascular diseases
Issue Date: 1-Nov-2018
Publisher: Medicina Oral SL
Abstract: Background: atherosclerotic cardiovascular disease is the main cause of mortality in developed countries. It is a chronic and systemic inflammatory disease with a multifactorial etiology. Periodontal disease is one of the many factors that contribute to its development. Objective: to analyze the effects of periodontal treatment on cardiovascular risk parameters in patients with atherosclerotic cardiovascular disease. Methods: a systematic research was conducted in the Pubmed/Medline databases for clinical trials published up to and including the year 2017. Results: ten articles were included for analysis. Periodontal treatment reduced C-reactive protein levels (77.8% of clinical trials), tumor necrosis factor-alpha (66.7%), interleukin-6 (100%) and leukocytes (50%). Fibrinogen levels also improved considerably (66.7%). Effects on lipid parameters were more limited, whereby only oxidized low density lipoprotein and very low density lipoprotein cholesterol decreased significantly. Meta-analysis showed a statistically significant decreased in C-reactive protein and leukocytes values when patients were submitted to non-surgical periodontal treatment in contrast to receiving no treatment at all (mean difference 1.199 mg/L, 95% confidence interval: 1.100-1.299, p<0.001; and mean difference 0,79 g/L, 95% confidence interval: 0.717-0.879, p<0.001, respectively). Conclusions: periodontal treatment has a beneficial effect on some of the biochemical parameters considered to represent cardiovascular risk. Further randomized clinical trials are necessary, with longer follow-up periods including regular periodic monitoring, in order to determine the extent of the impact of periodontal treatment.
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It is part of: Medicina Oral, Patología Oral y Cirugía Bucal, 2018, vol. 23, num. 6, p. 681-690
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ISSN: 1698-4447
Appears in Collections:Articles publicats en revistes (Odontoestomatologia)
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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