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Title: Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort
Author: Low, Dorrain Yanwen
Lefèvre Arbogast, Sophie
González-Domínguez, Raúl
Urpí Sardà, Mireia
Micheau, Pierre
Petera, Melanie
Centeno, Delphine
Durand, Stephanie
Pujos Guillot, Estelle
Korosi, Aniko
Lucassen, Paul J.
Aigner, Ludwig
Proust Lima, Cécile
Hejblum, Boris P.
Helmer, Catherine
Andrés Lacueva, Ma. Cristina
Thuret, Sandrine
Samieri, Cécilia
Manach, Claudine
Keywords: Metabòlits
Issue Date: 20-Jun-2019
Publisher: Wiley-VCH
Abstract: Scope: Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. Methods and results: A case-control study nested in the prospective Three-City study includes participants aged &65 years and initially free of dementia. A total of 209 cases of cognitive decline and 209 controls (matched for age, gen- der, education) with slower cognitive decline over up to 12 years are contrasted. Using untargeted metabolomics and bootstrap-enhanced penalized regression, a baseline serum signature of 22 metabolites associated with subsequent cognitive decline is identified. The signature includes three coffee metabolites, a biomarker of citrus intake, a cocoa metabolite, two metabolites putatively derived from fish and wine, three medium-chain acylcarnitines, glycodeoxycholic acid, lysoPC(18:3), trimethyllysine, glucose, cortisol, creatinine, and arginine. Adding the 22 metabolites to a reference predictive model for cognitive decline (conditioned on age, gender, education and including ApoE-ε4, diabetes, BMI, and number of medications) substantially increases the predictive performance: cross-validated Area Under the Receiver Operating Curve = 75% [95% CI 70-80%] compared to 62% [95% CI 56-67%]. Conclusions: The untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging.
Note: Versió postprint del document publicat a:
It is part of: Molecular Nutrition & Food Research, 2019, vol. 63, p. 1900177
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ISSN: 1613-4125
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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