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http://hdl.handle.net/2445/159039
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DC Field | Value | Language |
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dc.contributor.author | Guirado, Pedro | - |
dc.contributor.author | Paytubi Casabona, Sònia | - |
dc.contributor.author | Miró, Elisenda | - |
dc.contributor.author | Iglesias-Torrens, Yaidelis | - |
dc.contributor.author | Navarro, Ferran | - |
dc.contributor.author | Cerdà Cuéllar, Marta | - |
dc.contributor.author | Stephan-Otto Attolini, Camille | - |
dc.contributor.author | Balsalobre Parra, Carlos | - |
dc.contributor.author | Madrid Xufré, Cristina | - |
dc.date.accessioned | 2020-05-07T07:48:35Z | - |
dc.date.available | 2020-05-07T07:48:35Z | - |
dc.date.issued | 2020-02-26 | - |
dc.identifier.issn | 2076-2607 | - |
dc.identifier.uri | http://hdl.handle.net/2445/159039 | - |
dc.description.abstract | Campylobacter jejuni causes campylobacteriosis, a bacterial gastroenteritis with high incidence worldwide. Moreover, C. jejuni infection can trigger the polyneuropathic disorder denominated Guillain-Barré syndrome (GBS). The C. jejuni strains that can elicit GBS carry either wlaN or cgtB, coding both genes for a β-1,3-galactosyltransferase enzyme that is required for the production of sialylated lipooligosaccharide (LOSSIAL). We described a differential prevalence of the genes wlaN and cgtB in C. jejuni isolates from three different ecological niches: humans, broiler chickens, and wild birds. The distribution of both genes, which is similar between broiler chicken and human isolates and distinct when compared to the wild bird isolates, suggests a host-dependent distribution. Moreover, the prevalence of the wlaN and cgtB genes seems to be restricted to some clonal complexes. Gene sequencing identified the presence of new variants of the G- homopolymeric tract within the wlaN gene. Furthermore, we detected two variants of a G rich region within the cgtBgene, suggesting that, similarly to wlaN, the G-tract in the cgtB gene mediates the phase variation control of cgtB expression. Caco-2 cell invasion assays indicate that there is no evident correlation between the production of LOSSIAL and the ability to invade eukaryotic cells. | - |
dc.format.extent | 12 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/microorganisms8030325 | - |
dc.relation.ispartof | Microorganisms, 2020, vol. 8, p. 325 | - |
dc.relation.uri | https://doi.org/10.3390/microorganisms8030325 | - |
dc.rights | cc-by (c) Guirado, Pedro et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Malalties del sistema nerviós | - |
dc.subject.classification | Malalties autoimmunitàries | - |
dc.subject.other | Nervous system Diseases | - |
dc.subject.other | Autoimmune diseases | - |
dc.title | Differential distribution fo the wlaN and cgtB genes, associated with Guillain-Barré syndrome, in Campylobacter jejuni isolates from humans, broiler chickens, and wild birds | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 699236 | - |
dc.date.updated | 2020-05-07T07:48:36Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32110976 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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699236.pdf | 848.85 kB | Adobe PDF | View/Open |
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