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Title: | Differential distribution fo the wlaN and cgtB genes, associated with Guillain-Barré syndrome, in Campylobacter jejuni isolates from humans, broiler chickens, and wild birds |
Author: | Guirado, Pedro Paytubi Casabona, Sònia Miró, Elisenda Iglesias-Torrens, Yaidelis Navarro, Ferran Cerdà Cuéllar, Marta Stephan-Otto Attolini, Camille Balsalobre Parra, Carlos Madrid Xufré, Cristina |
Keywords: | Malalties del sistema nerviós Malalties autoimmunitàries Nervous system Diseases Autoimmune diseases |
Issue Date: | 26-Feb-2020 |
Publisher: | MDPI |
Abstract: | Campylobacter jejuni causes campylobacteriosis, a bacterial gastroenteritis with high incidence worldwide. Moreover, C. jejuni infection can trigger the polyneuropathic disorder denominated Guillain-Barré syndrome (GBS). The C. jejuni strains that can elicit GBS carry either wlaN or cgtB, coding both genes for a β-1,3-galactosyltransferase enzyme that is required for the production of sialylated lipooligosaccharide (LOSSIAL). We described a differential prevalence of the genes wlaN and cgtB in C. jejuni isolates from three different ecological niches: humans, broiler chickens, and wild birds. The distribution of both genes, which is similar between broiler chicken and human isolates and distinct when compared to the wild bird isolates, suggests a host-dependent distribution. Moreover, the prevalence of the wlaN and cgtB genes seems to be restricted to some clonal complexes. Gene sequencing identified the presence of new variants of the G- homopolymeric tract within the wlaN gene. Furthermore, we detected two variants of a G rich region within the cgtBgene, suggesting that, similarly to wlaN, the G-tract in the cgtB gene mediates the phase variation control of cgtB expression. Caco-2 cell invasion assays indicate that there is no evident correlation between the production of LOSSIAL and the ability to invade eukaryotic cells. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/microorganisms8030325 |
It is part of: | Microorganisms, 2020, vol. 8, p. 325 |
URI: | http://hdl.handle.net/2445/159039 |
Related resource: | https://doi.org/10.3390/microorganisms8030325 |
ISSN: | 2076-2607 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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