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Title: FGF21 mediates the lipid metabolism response to amino acid starvation
Author: Sousa Coelho, Ana Luisa de
Relat Pardo, Joana
Hondares, E.
Pérez Martí, Albert
Ribas Aulinas, Francesc
Villarroya i Gombau, Francesc
Marrero González, Pedro F.
Haro Bautista, Diego
Keywords: Metabolisme dels lípids
Teixit adipós
Factors de creixement
Lipid metabolism
Adipose tissues
Growth factors
Amino acids
Issue Date: 9-May-2013
Publisher: American Society for Biochemistry and Molecular Biology
Abstract: Abstract Lipogenic gene expression in liver is repressed in mice upon leucine deprivation. The hormone fi broblast growth factor 21 (FGF21), which is critical to the adaptive metabolic response to starvation, is also induced under amino acid deprivation. Upon leucine deprivation, we found that FGF21 is needed to repress expression of lipogenic genes in liver and white adipose tissue, and stimulate phosphorylation of hormone-sensitive lipase in white adipose tissue. The increased expression of Ucp1 in brown adipose tissue under these circumstances is also impaired in FGF21- defi cient mice. Our results demonstrate the important role of FGF21 in the regulation of lipid metabolism during amino acid starvation. ¿De Sousa-Coelho, A. L., J. Relat, E. Hondares, A. Pérez-Martí, F. Ribas, F. Villarroya, P. F. Marrero, and D. Haro. FGF21 mediates the lipid metabolism response to amino acid starvation.
Note: Reproducció del document publicat a:
It is part of: Journal of Lipid Research, 2013, vol. 54, num. 7, p. 1786-1797
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ISSN: 0022-2275
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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