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Title: | Eubiotic effect of buckwheat D-fagomine in healthy rats |
Author: | Hereu, Mercè Ramos Romero, Sara García-González, Natalia Amézqueta, Susana Torres, Josep Lluís |
Keywords: | Lactobacils Microbiota Bifidobacteris Lactobacillus Microbiota Bifidobacterium |
Issue Date: | 16-Sep-2018 |
Publisher: | Elsevier |
Abstract: | Diversity and balance of gut microorganisms is fundamental for health throughout life. The aim of this study is to explore the possible eubiotic effect of the buckwheat iminosugar D-fagomine (0.096% w/w in standard feed) in growing healthy Wistar Kyoto rats. Feed and energy intake, residual energy in feces, and body weight gain were independent of D-fagomine supplementation throughout the intervention (24 weeks). The populations of significant bacterial subgroups and species were determined in fecal and cecal DNA by quantitative real-time PCR. D-Fagomine increased the Bacteroidetes:Firmicutes ratio and partially counteracted the loss of Lactobacilliales and Bifidobacteriales over time. The supplementation reduced the levels of excreted short- chain fatty acids (SCFAs) as determined by gas chromatography. This paper provides preliminary evidence that D-fagomine has the capacity to promote microbial functional diversity by increasing the Bacteroidetes:Firmicutes ratio and to mitigate the age-related reduction in populations of the putatively beneficial Lactobacilliales and Bifidobacteriales. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.jff.2018.09.018 |
It is part of: | Journal of Functional Foods, 2018, vol. 50, p. 120-126 |
URI: | http://hdl.handle.net/2445/162310 |
Related resource: | https://doi.org/10.1016/j.jff.2018.09.018 |
ISSN: | 1756-4646 |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
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