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http://hdl.handle.net/2445/162398
Title: | Exploring the Molecular Pathways Behind the Effects of Nutrients and Dietary Polyphenols on Gut Microbiota and Intestinal Permeability: A Perspective on the Potential of Metabolomics and Future Clinical Applications. |
Author: | Peron, Gregorio Hidalgo Liberona, Nicole González-Domínguez, Raúl Garcia Aloy, Mar Guglielmetti, Simone Bernardi, Stefano Kirkup, Benjamin Kroon, Paul A. Cherubini, Antonio Riso, Patrizia Andrés Lacueva, Ma. Cristina |
Keywords: | Microbiologia Microbiota intestinal Metabolisme Polifenols Metabolòmica Envelliment Mucosa gastrointestinal Microbiology Gastrointestinal microbiome Metabolism Polyphenols Metabolomics Aging Gastrointestinal mucosa |
Issue Date: | 14-May-2019 |
Publisher: | American Chemical Society |
Abstract: | The gut microbiota is involved in the regulation of the intestinal permeability (IP), whose disruption is a frequent condition in older people and is associated with the development of several diseases. The diet can affect the gut microbiota and IP, although the molecular mechanisms involved are unclear. Metabolomics is one of the suitable approaches to study the effects of diet on gut microbiota and IP, although, up to now, the research has focused only on a few dietary components. The aim here was to review the most recent literature concerning the application of metabolomics to the study of the diet-induced alterations of gut microbiota and the effects on IP, with a particular focus on the molecular pathways involved. An additional aim was to give a perspective on the future research involving dietary polyphenols, because despite their potential use in the management of increased IP, few studies have been reported to date. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1021/acs.jafc.9b01687 |
It is part of: | Journal of Agricultural and Food Chemistry, 2019, vol. 68, num. 7, p. 1780-1789 |
URI: | http://hdl.handle.net/2445/162398 |
Related resource: | https://doi.org/10.1021/acs.jafc.9b01687 |
ISSN: | 0021-8561 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB)) Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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