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http://hdl.handle.net/2445/162499
Title: | Experimental evidence of symmetry breaking of transition-path times |
Author: | Gladrow, J. Ribezzi-Crivellari, M. Ritort Farran, Fèlix Keyser, U.F. |
Keywords: | Energia Col·loides Moviment brownià ADN Energy Colloids Brownian movements DNA |
Issue Date: | 4-Jan-2019 |
Publisher: | Nature Publishing Group |
Abstract: | While thermal rates of state transitions in classical systems have been studied for almost a century, associated transition-path times have only recently received attention. Uphill and downhill transition paths between states at different free energies should be statistically indistinguishable. Here, we systematically investigate transition-path-time symmetry and report evidence of its breakdown on the molecular- and meso-scale out of equilibrium. In automated Brownian dynamics experiments, we establish first-passage-time symmetries of colloids driven by femtoNewton forces in holographically-created optical landscapes confined within microchannels. Conversely, we show that transitions which couple in a path-dependent manner to fluctuating forces exhibit asymmetry. We reproduce this asymmetry in folding transitions of DNA-hairpins driven out of equilibrium and suggest a topological mechanism of symmetry breakdown. Our results are relevant to measurements that capture a single coordinate in a multidimensional free energy landscape, as encountered in electrophysiology and single-molecule fluorescence experiments. |
Note: | Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-07873-9 |
It is part of: | Nature Communications, 2019, vol. 10, p. 55 |
URI: | http://hdl.handle.net/2445/162499 |
Related resource: | https://doi.org/10.1038/s41467-018-07873-9 |
ISSN: | 2041-1723 |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) Publicacions de projectes de recerca finançats per la UE |
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