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Title: Fibroblast Growth Factor 21 and the Adaptive Response to Nutritional Challenges.
Author: Martínez Garza, Úrsula
Torres-Oteros, Daniel
Yarritu-Gallego, Alex
Marrero González, Pedro F.
Haro Bautista, Diego
Relat Pardo, Joana
Keywords: Metabolisme
Expressió gènica
Resistència a la insulina
Proteïnes de membrana
Teixit adipós
Hàbits alimentaris
Gene expression
Insulin resistance
Membrane proteins
Adipose tissues
Food habits
Issue Date: 21-Sep-2019
Publisher: MDPI
Abstract: The Fibroblast Growth Factor 21 (FGF21) is considered an attractive therapeutic target for obesity and obesity-related disorders due to its beneficial effects in lipid and carbohydrate metabolism. FGF21 response is essential under stressful conditions and its metabolic effects depend on the inducer factor or stress condition. FGF21 seems to be the key signal which communicates and coordinates the metabolic response to reverse different nutritional stresses and restores the metabolic homeostasis. This review is focused on describing individually the FGF21-dependent metabolic response activated by some of the most common nutritional challenges, the signal pathways triggering this response, and the impact of this response on global homeostasis. We consider that this is essential knowledge to identify the potential role of FGF21 in the onset and progression of some of the most prevalent metabolic pathologies and to understand the potential of FGF21 as a target for these diseases. After this review, we conclude that more research is needed to understand the mechanisms underlying the role of FGF21 in macronutrient preference and food intake behavior, but also in β-klotho regulation and the activity of the fibroblast activation protein (FAP) to uncover its therapeutic potential as a way to increase the FGF21 signaling.
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It is part of: International Journal of Molecular Sciences, 2019, vol. 20, num. 19, p. E4692
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ISSN: 1661-6596
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB))

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