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Title: | Human hydroxytyrosol's absorption and excretion from a nutraceutical |
Author: | Khymenets, Olha Crespo, M. Carmen Dangles, Olivier Rakotomanomana, N. Andrés Lacueva, Ma. Cristina Visioli, F. (Francesco) |
Keywords: | Salut Suplements nutritius Espectrometria de masses Biodisponibilitat Assaigs clínics Metabòlits Polifenols Orina Health Dietary supplements Mass spectrometry Bioavailability Clinical trials Metabolites Polyphenols Urine |
Issue Date: | 31-Mar-2016 |
Publisher: | Elsevier |
Abstract: | Among the various (poly)phenols that are being sold as such or as part of a more complex mixture, hydroxytyrosol (HT) is the only one that bears a European Food Safety Authority health claim. Therefore, several HT-based products are being developed and sold and it becomes necessary to evaluate its accessibility following ingestion. Twenty-one volunteers were recruited for a randomized, crossover, placebo-controlled, and double-blind intervention study.We performed a Latin square design: after one-week washout, i.e. olive-free diet, subjects were randomly assigned to the placebo (maltodextrin), 5, or 25 mg/day HT group. Twenty-four hour urine samples were collected after the intervention week, and baseline urines were collected the week before the study and during periods of washout. The results show that HT given as the foremost component of a nutraceutical preparation is bioavailable and is recovered in the urine chiefly as sulphate-3′. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.jff.2016.02.046 |
It is part of: | Journal of Functional Foods, 2016, vol. 23, num. , p. 278-282 |
URI: | http://hdl.handle.net/2445/164059 |
Related resource: | https://doi.org/10.1016/j.jff.2016.02.046 |
ISSN: | 1756-4646 |
Appears in Collections: | Articles publicats en revistes (Institut de Recerca en Nutrició i Seguretat Alimentària (INSA·UB)) Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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