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Title: Short time guided bone regeneration using beta-tricalcium phosphate with and without fibronectin. An experimental study in rats
Author: Sánchez Garcés, Ma. Ángeles
Camps Font, Octavi
Escoda Francolí, Jaume
Muñoz Guzón, Fernando
Toledano Serrabona, Jorge
Gay Escoda, Cosme
Keywords: Regeneració (Biologia)
Malalties dels ossos
Rates (Animals de laboratori)
Regeneration (Biology)
Bone diseases
Rats as laboratory animals
Issue Date: 2020
Publisher: Medicina Oral SL
Abstract: Background: The aim of this histomorphometric study was to assess the bone regeneration potential of beta-tricalcium phosphate with fibronectin (β-TCP-Fn) in critical-sized defects (CSDs) in rats calvarial, to know whether Fn improves the new bone formation in a short time scope. Material and Methods: CSDs were created in 30 Sprague Dawley rats, and divided into four groups (2 or 6 weeks of healing) and type of filling (β-TCP-Fn, β-TCP, empty control). Variables studied were augmented area (AA), gained tissue (GT), mineralized/non mineralized bone matrix (MBM/NMT) and bone substitute (BS). Results: 60 samples at 2 and six weeks were evaluated. AA was higher for treatment groups comparing to controls (p < 0.001) and significant decrease in BS area in the β-TCP-Fn group from 2 to 6 weeks (p = 0.031). GT was higher in the β-TCP-Fn group than in the controls expressed in % (p = 0.028) and in mm2 (p = 0.011), specially at two weeks (p=0.056). Conclusions: Both β-TCP biomaterials are effective as compared with bone defects left empty in maintaining the volume. GT in defects regeneration filed with β-TCP-Fn are significantly better in short healing time when comparing with controls but not for β-TCP used alone in rats calvarial CSDs.
Note: Reproducció del document publicat a:
It is part of: Medicina Oral, Patología Oral y Cirugía Bucal, 2020, vol. 25, num. 4, p. e532-e540
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ISSN: 1698-4447
Appears in Collections:Articles publicats en revistes (Odontoestomatologia)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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