Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/175204
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leroy, Sandrine | - |
dc.contributor.author | Bouissou, François | - |
dc.contributor.author | Fernández López, Anna | - |
dc.contributor.author | Gurgoze, Metin K. | - |
dc.contributor.author | Karavanaki, Kyriaki | - |
dc.contributor.author | Ulinski, Tim | - |
dc.contributor.author | Bressan, Silvia | - |
dc.contributor.author | Vaos, Geogios | - |
dc.contributor.author | Leblond, Pierre | - |
dc.contributor.author | Coulais, Yvon | - |
dc.contributor.author | Luaces Cubells, Carles | - |
dc.contributor.author | Aygun, A. Denizmen | - |
dc.contributor.author | Stefanidis, Constantinos J. | - |
dc.contributor.author | Bensman, Albert | - |
dc.contributor.author | DaDalt, Liviana | - |
dc.contributor.author | Gardikis, Stefanos | - |
dc.contributor.author | Bigot, Sandra | - |
dc.contributor.author | Gendrel, Dominique | - |
dc.contributor.author | Bréart, Gérard | - |
dc.contributor.author | Chalumeau, Martin | - |
dc.date.accessioned | 2021-03-17T10:05:37Z | - |
dc.date.available | 2021-03-17T10:05:37Z | - |
dc.date.issued | 2011-12-28 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175204 | - |
dc.description.abstract | Background: Predicting vesico-ureteral reflux (VUR) ≥3 at the time of the first urinary tract infection (UTI) would make it possible to restrict cystography to high-risk children. We previously derived the following clinical decision rule for that purpose: cystography should be performed in cases with ureteral dilation and a serum procalcitonin level ≥0.17 ng/mL, or without ureteral dilatation when the serum procalcitonin level ≥0.63 ng/mL. The rule yielded a 86% sensitivity with a 46% specificity. We aimed to test its reproducibility. Study design: A secondary analysis of prospective series of children with a first UTI. The rule was applied, and predictive ability was calculated. Results: The study included 413 patients (157 boys, VUR ≥3 in 11%) from eight centers in five countries. The rule offered a 46% specificity (95% CI, 41-52), not different from the one in the derivation study. However, the sensitivity significantly decreased to 64% (95%CI, 50-76), leading to a difference of 20% (95%CI, 17-36). In all, 16 (34%) patients among the 47 with VUR ≥3 were misdiagnosed by the rule. This lack of reproducibility might result primarily from a difference between derivation and validation populations regarding inflammatory parameters (CRP, PCT); the validation set samples may have been collected earlier than for the derivation one. Conclusions: The rule built to predict VUR ≥3 had a stable specificity (ie. 46%), but a decreased sensitivity (ie. 64%) because of the time variability of PCT measurement. Some refinement may be warranted. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0029556 | - |
dc.relation.ispartof | PLoS One, 2011, vol. 6, num. 12, p. e29556 | - |
dc.relation.uri | https://doi.org/10.1371/journal.pone.0029556 | - |
dc.rights | cc-by (c) Leroy, Sandrine et al., 2011 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) | - |
dc.subject.classification | Infeccions del tracte urinari | - |
dc.subject.classification | Pediatria | - |
dc.subject.other | Urinary tract infections | - |
dc.subject.other | Pediatrics | - |
dc.title | Prediction of High-Grade Vesicoureteral Reflux after Pediatric Urinary Tract Infection: External Validation Study of Procalcitonin-Based Decision Rule | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 692799 | - |
dc.date.updated | 2021-03-17T10:05:37Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22216314 | - |
Appears in Collections: | Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
692799.pdf | 465.44 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License