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http://hdl.handle.net/2445/175889
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DC Field | Value | Language |
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dc.contributor.author | Thorneywork, Alice L. | - |
dc.contributor.author | Gladrow, J. | - |
dc.contributor.author | Qing, Yujia | - |
dc.contributor.author | Rico Pastó, Marc | - |
dc.contributor.author | Ritort Farran, Fèlix | - |
dc.contributor.author | Bayley, Hagan | - |
dc.contributor.author | Kolomeisky, Anatoly B. | - |
dc.contributor.author | Keyser, U.F. | - |
dc.date.accessioned | 2021-03-30T15:58:09Z | - |
dc.date.available | 2021-03-30T15:58:09Z | - |
dc.date.issued | 2020-04-01 | - |
dc.identifier.issn | 2375-2548 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175889 | - |
dc.description.abstract | All natural phenomena are governed by energy landscapes. However, the direct measurement of this fundamen-tal quantity remains challenging, particularly in complex systems involving intermediate states. Here, we uncover key details of the energy landscapes that underpin a range of experimental systems through quantitative analysis of first-passage time distributions. By combined study of colloidal dynamics in confinement, transport through a biological pore, and the folding kinetics of DNA hairpins, we demonstrate conclusively how a short-time, power-law regime of the first-passage time distribution reflects the number of intermediate states associated with each of these processes, despite their differing length scales, time scales, and interactions. We thereby establish a powerful method for investigating the underlying mechanisms of complex molecular processes. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for the Advancement of Science | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1126/sciadv.aaz4642 | - |
dc.relation.ispartof | Science Advances, 2020, vol. 6, num. 18, p. eaaz4642 | - |
dc.relation.uri | https://doi.org/10.1126/sciadv.aaz4642 | - |
dc.rights | cc-by-nc (c) Thorneywork, Alice L. et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/3.0/es | - |
dc.source | Articles publicats en revistes (Física de la Matèria Condensada) | - |
dc.subject.classification | Microfluídica | - |
dc.subject.classification | Col·loides | - |
dc.subject.classification | Cinètica química | - |
dc.subject.other | Microfluidics | - |
dc.subject.other | Colloids | - |
dc.subject.other | Chemical kinetics | - |
dc.title | Direct detection of molecular intermediates from first-passage times | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 709676 | - |
dc.date.updated | 2021-03-30T15:58:09Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/647144/EU//DesignerPores | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/674979/EU//NANOTRANS | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/294443/EU//COSIMO | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32494675 | - |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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709676.pdf | 1.63 MB | Adobe PDF | View/Open |
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