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Title: | Direct detection of molecular intermediates from first-passage times |
Author: | Thorneywork, Alice L. Gladrow, J. Qing, Yujia Rico Pastó, Marc Ritort Farran, Fèlix Bayley, Hagan Kolomeisky, Anatoly B. Keyser, U.F. |
Keywords: | Microfluídica Col·loides Cinètica química Microfluidics Colloids Chemical kinetics |
Issue Date: | 1-Apr-2020 |
Publisher: | American Association for the Advancement of Science |
Abstract: | All natural phenomena are governed by energy landscapes. However, the direct measurement of this fundamen-tal quantity remains challenging, particularly in complex systems involving intermediate states. Here, we uncover key details of the energy landscapes that underpin a range of experimental systems through quantitative analysis of first-passage time distributions. By combined study of colloidal dynamics in confinement, transport through a biological pore, and the folding kinetics of DNA hairpins, we demonstrate conclusively how a short-time, power-law regime of the first-passage time distribution reflects the number of intermediate states associated with each of these processes, despite their differing length scales, time scales, and interactions. We thereby establish a powerful method for investigating the underlying mechanisms of complex molecular processes. |
Note: | Reproducció del document publicat a: https://doi.org/10.1126/sciadv.aaz4642 |
It is part of: | Science Advances, 2020, vol. 6, num. 18, p. eaaz4642 |
URI: | http://hdl.handle.net/2445/175889 |
Related resource: | https://doi.org/10.1126/sciadv.aaz4642 |
ISSN: | 2375-2548 |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) Publicacions de projectes de recerca finançats per la UE |
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