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2020-11-19

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cc-by (c) Campderrós, Laura et al., 2020
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/176645

Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners

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Recurs relacionat

https://doi.org/10.3389/fphys.2020.550102

Resum

Background: Recreational marathon runners face strong physiological challenges. Assessment of potential biomarkers for the biological responses of runners will help to discriminate individual race responsiveness and their physiological consequences. This study sought to analyze the changes in the plasma levels of GDF15 and FGF21, novel endocrine factors related to metabolic stress, in runners following the strenuous exercise of a marathon race. Methods: Blood samples were obtained from eighteen male runners (mean ±SD, age: 41.7 ±5.0 years, BMI: 23.6 ± 1.8) 48 h before, immediately after, and 48 h after a marathon race, and from age-matched sedentary individuals. The level of GDF15, FGF21, and 38 additional biochemical and hematological parameters were determined. Results: The basal levels of GDF15 and FGF21 did not differ between runners before the race and sedentary individuals. Significant increases in the mean levels of GDF15 (4.2-fold) and FGF21 (20-fold) were found in runners immediately after the race. The magnitudes of these increases differed markedly among individuals and did not correlate with each other. The GDF15 and FGF21 levels had returned to the basal level 48 h post-race. The post-race value of GDF15 (but not FGF21) correlated positively with increased total white cell count (r = 0.50, P = 0.01) and neutrophilia (r = 0.10, P = 0.01). Conclusion: GDF15 and FGF21 are transiently increased in runners following a marathon race. The induction of GDF15 levels is associated with alterations in circulating immune cells levels.

Matèries

Marató, Condició física, Marcadors bioquímics

Matèries (anglès)

Marathon running, Physical fitness, Biochemical markers

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Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

Citació

CAMPDERRÓS TRAVER, Laura, SÁNCHEZ INFANTES, David, VILLARROYA TERRADE, Joan, NESCOLARDE, Lexa, BAYÉS GENÍS, Antoni, CEREIJO TÉLLEZ, Rubén, ROCA, Emma, VILLARROYA I GOMBAU, Francesc. Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise: A Study in Marathon Runners. _Frontiers in Physiology_. 2020. Vol. 11, núm. 550102. [consulta: 2 de gener de 2026]. ISSN: 1664-042X. [Disponible a: https://hdl.handle.net/2445/176645]

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