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Title: Mapping co-ancestry connections between the genome of a Medieval individual and modern Europeans
Author: Ferrando Bernal, Manuel
Morcillo Suárez, Carlos
de Dios, Toni
Gelabert, Pere
Civit Vives, Sergi
Díaz Carvajal, Antonia
Ollich i Castanyer, Imma, 1951-
Allentoft, Morten E.
Valverde, Sergi
Lalueza Fox, Carles, 1965-
Keywords: Relacions intergeneracionals
ADN fòssil
Intergenerational relations
Fossil DNA
Issue Date: 22-Apr-2020
Publisher: Nature Publishing Group
Abstract: Historical genetic links among similar populations can be difficult to establish. Identity by descent (IBD) analyses find genomic blocks that represent direct genealogical relationships among individuals. However, this method has rarely been applied to ancient genomes because IBD stretches are progressively fragmented by recombination and thus not recognizable after few tens of generations. To explore such genealogical relationships, we estimated long IBD blocks among modern Europeans, generating networks to uncover the genetic structures. We found that Basques, Sardinians, Icelanders and Orcadians form, each of them, highly intraconnected sub-clusters in a European network, indicating dense genealogical links within small, isolated populations. We also exposed individual genealogical links -such as the connection between one Basque and one Icelandic individual- that cannot be uncovered with other, widely used population genetics methods such as PCA or ADMIXTURE. Moreover, using ancient DNA technology we sequenced a Late Medieval individual (Barcelona, Spain) to high genomic coverage and identified IBD blocks shared between her and modern Europeans. The Medieval IBD blocks are statistically overrepresented only in modern Spaniards, which is the geographically closest population. This approach can be used to produce a fine-scale reflection of shared ancestry across different populations of the world, offering a direct genetic link from the past to the present.
Note: Reproducció del document publicat a:
It is part of: Scientific Reports, 2020, vol. 10, num. 1, p. 6483
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ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Grup de Recerca d'Arqueologia Medieval i Postmedieval, GRAMP-UB)
Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Història i Arqueologia)

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