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Title: Adipose tissue knockdown of lysozyme reduces local inflammation and improves adipogenesis in high-fat diet-fed mice
Author: Latorre, Jèssica
Lluch, Aina
Ortega, Francisco J.
Gavaldà i Navarro, Aleix
Comas, Ferran
Morón-Ros, Samantha
Rodríguez, Amaia
Becerril, Sara
Villarroya i Gombau, Francesc
Frühbeck, Gema
Ricart, Wifredo
Giralt i Oms, Marta
Fernández-Real, José Manuel
Moreno-Navarrete, José M.
Keywords: Teixit adipós
Adipose tissues
Issue Date: 5-Feb-2021
Publisher: Elsevier B.V.
Abstract: Chronic systemic low-level inflammation in metabolic disease is known to affect adipose tissue biology. Lysozyme (LYZ) is a major innate immune protein but its role in adipose tissue has not been investigated. Here, we aimed to investigate LYZ in human and rodents fat depots, and its possible role in obesity-associated adipose tissue dysfunction. LYZ mRNA and protein were identified to be highly expressed in adipose tissue from subjects with obesity and linked to systemic chronic-low grade inflammation, adipose tissue inflammation and metabolic disturbances, including hyperglycemia, dyslipidemia and decreased markers of adipose tissue adipogenesis. These findings were confirmed in experimental models after a high-fat diet in mice and rats and also in ob/ob mice. Importantly, specific inguinal and perigonadal white adipose tissue lysozyme (Lyz2) gene knockdown in high-fat diet-fed mice resulted in improved adipose tissue inflammation in parallel to reduced lysozyme activity. Of note, Lyz2 gene knockdown restored adipogenesis and reduced weight gain in this model. In conclusion, altogether these observations point to lysozyme as a new actor in obesity-associated adipose tissue dysfunction. The therapeutic targeting of lysozyme production might contribute to improve adipose tissue metabolic homeostasis.
Note: Versió postprint del document publicat a:
It is part of: Pharmacological Research, 2021, vol. 166, p. 105486
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ISSN: 1043-6618
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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