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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/181214
Signature of circulating biomarkers in recurrent non-infectious anterior uveitis. Immunomodulatory effects of DHA-triglyceride. A pilot study.
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The purpose of this study was to identify circulating biomarkers of recurrent non-infectious anterior uveitis (NIAU), and to address the anti-inflammatory effects of triglyceride containing docosahexaenoic acid (DHA-TG). A prospective multicenter study was conducted in 72 participants distributed into: patients diagnosed with recurrent NIAU in the quiescence stage (uveitis group (UG); n = 36) and healthy controls (control group (CG); n = 36). Each group was randomly assigned to the oral supplementation of one pill/day (+) containing DHA-TG (n = 18) or no-pill condition (-) (n = 17) for three consecutive months. Data from demographics, risk factors, comorbidities, eye complications and therapy were recorded. Blood was collected and processed to determine pro-inflammatory biomarkers by bead-base multiplex assay. Statistical processing with multivariate statistical analysis was performed. The mean age was 50, 12 (10, 31) years. The distribution by gender was 45% males and 55% females. The mean number of uveitis episodes was 5 (2). Higher plasma expression of interleukin (IL)-6 was detected in the UG versus the CG (p = 5 × 10-5). Likewise, significantly higher plasma levels were seen for IL-1β, IL-2, INFγ (p = 10-4), and TNFα (p = 2 × 10-4) in the UG versus the CG. Significantly lower values of the above molecules were found in the +DHA-TG than in the -DHA-TG subgroups, after 3 months of follow-up, TNFα (p = 10-7) and IL-6 (p = 3 × 10-6) being those that most significantly changed. Signatures of circulating inflammatory mediators were obtained in the quiescent stage of recurrent NIAU patients. This 3-month follow-up strongly reinforces that a regular oral administration of DHA-TG reduces the inflammatory load and may potentially supply a prophylaxis-adjunctive mediator for patients at risk of uveitis vision los
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PINAZO DURÁN, María dolores, GARCÍA MEDINA, Jose j., SANZ-GONZÁLEZ, Silvia m., O'CONNOR, José enrique, CASAROLI MARANO, Ricardo pedro, VALERO VELLÓ, Mar, LÓPEZ GÁLVEZ, María isabel, PERIS MARTÍNEZ, Cristina, ZANÓN MORENO, Vicente, DÍAZ LLOPIS, Manuel. Signature of circulating biomarkers in recurrent non-infectious anterior uveitis. Immunomodulatory effects of DHA-triglyceride. A pilot study.. _Diagnostics_. 2021. Vol. 11, núm. 724. [consulta: 10 de desembre de 2025]. ISSN: 2075-4418. [Disponible a: https://hdl.handle.net/2445/181214]