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2021-08-31

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cc-by-nc-nd (c) Vukomanovic, Marija et al., 2021
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/185635

Nano-engineering stable contact-based antimicrobials: chemistry at the interface between nano-gold and bacteria.

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Contact-based antimicrobials, as antibiotic-free technologies that use non-specific interactions with bacterial cells to exert antimicrobial activity, are a prospective solution in fighting the global issue of bacterial resistance. A very simplified approach to their design considers the direct bonding of cationic guanidine-containing amino acids to the surface of nano-gold carriers. The structure enables antimicrobial activity due to a high density of cationic surface charges. This opens a set of novel questions that are important for their effective engineering, particularly regarding (i) chemistry and events that take place at the interface between NPs and cells, (ii) the direct influence of a charge (and its change) on interactions with bacterial and mammalian cells, and (iii) the stability of structures (and their antimicrobial activity) in the presence of enzymes, which are addressed in this paper. Because of the ability of amino acid-functionalized nano-gold to retain structural and functional activity, even after exposure to a range of physicochemical stimuli, they provide an excellent nanotechnological platform for designing highly effective contact-based antimicrobials and their applications.

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Enzims microbians, Aminoàcids

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Microbial enzymes, Amino acids

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Articles publicats en revistes (Genètica, Microbiologia i Estadística)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

Citació

VUKOMANOVIC, Marija, CENDRA GASCÓN, María del mar, BAELO, Aida, TORRENTS SERRA, Eduard. Nano-engineering stable contact-based antimicrobials: chemistry at the interface between nano-gold and bacteria.. _Colloids and Surfaces B-Biointerfaces_. 2021. Vol. 208, núm. 112083. [consulta: 10 de desembre de 2025]. ISSN: 0927-7765. [Disponible a: https://hdl.handle.net/2445/185635]

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