Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/192552
Title: | The relevance of urolithins-based metabotyping for assessing the effects of a polyphenol-rich dietary intervention on intestinal permeability: A post-hoc analysis of the MaPLE trial |
Author: | Meroño, Tomás Peron, Gregorio Gargari, Giorgio González-Domínguez, Raúl Miñarro Alonso, Antonio Vegas Lozano, Esteban Hidalgo Liberona, Nicole Del Bo, Cristian Bernardi, Stefano Kroon, Paul A. Carrieri, Barbara Cherubini, Antonio Riso, Patrizia Guglielmetti, Simone Andrés Lacueva, Ma. Cristina |
Keywords: | Polifenols Envelliment Microbiota Polyphenols Aging Microbiota |
Issue Date: | 1-Sep-2022 |
Publisher: | Elsevier B.V. |
Abstract: | A polyphenol-rich diet reduced intestinal permeability (IP) in older adults. Our aim was to evaluate if participants categorized according to urolithin metabotypes (UMs) exhibited different responses in the MaPLE trial. Fifty-one older adults (mean age: 78 years) completed an 8-week randomized-controlled-crossover trial comparing the effects of a polyphenol-rich vs. a control diet on IP, assessed through zonulin levels. Plasma and urinary metabolomics were evaluated with a semi-targeted UHPLC-MS/MS method. Gut microbiota was characterized by 16S rRNA gene profiling. UMs were determined according to urolithin excretion in 24 h urine samples. Multivariate statistics were used to characterize the differences in metabolomic and metataxonomic responses across UMs. Thirty-three participants were classified as urolithin metabotype A (UMA), 13 as urolithin metabotype B (UMB), and 5 as urolithin metabotype 0 (UM0) according to their urinary excretion of urolithins. Clinical, dietary, and biochemical characteristics at baseline were similar between UMs (all p > 0.05). After the polyphenol-rich diet, UMB vs. UMA participants showed a 2-fold higher improvement of zonulin levels (p for interaction = 0.033). Moreover, UMB vs. UMA participants were characterized for alterations in fatty acid metabolism, kynurenine pathway of tryptophan catabolism, and microbial metabolization of phenolic acids. These changes were correlated with the reduction of zonulin levels and modifications of gut microbes (increased Clostridiales, including, R. lactaris, and G. formicilis). In conclusion, urolithin-based metabotyping identified older adults with a higher improvement of IP after a polyphenol-rich diet. Our results reinforce the concept that UMs may contribute to tailor personalized nutrition interventions. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.foodres.2022.111632 |
It is part of: | Food Research International, 2022, vol. 159 |
URI: | http://hdl.handle.net/2445/192552 |
Related resource: | https://doi.org/10.1016/j.foodres.2022.111632 |
ISSN: | 0963-9969 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
724407.pdf | 1.15 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License