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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/193594
Decoding stem cells: an overview on planarian stem cell heterogeneity and lineage progression
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Planarians are flatworms capable of whole-body regeneration, able to regrow any missing body part after injury or amputation. The extraordinary regenerative capacity of planarians is based upon the presence in the adult of a large population of somatic pluripotent stem cells. These cells, called neoblasts, offer a unique system to study the process of stem cell specification and differentiation in vivo. In recent years, FACS-based isolation of neoblasts, RNAi functional analyses as well as high-throughput approaches such as single-cell sequencing have allowed a rapid progress in our understanding of many different aspects of neoblast biology. Here, we summarize our current knowledge on the molecular signatures that define planarian neoblasts heterogeneity, which includes a percentage of truly pluripotent stem cells, and guide the commitment of pluripotent neoblasts into lineage-specific progenitor cells, as well as their differentiation into specific planarian cell types.
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MOLINA JIMÉNEZ, M. Dolores and CEBRIÀ SÁNCHEZ, Francesc. Decoding stem cells: an overview on planarian stem cell heterogeneity and lineage progression. Biomolecules. 2021. Vol. 11, num. 10, pags. 1532. ISSN 2218-273X. [consulted: 25 of August of 2026]. Available at: https://hdl.handle.net/2445/193594