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Title: Decoding stem cells: an overview on planarian stem cell heterogeneity and lineage progression
Author: Molina Jiménez, M. Dolores
Cebrià Sánchez, Francesc
Keywords: Cèl·lules mare
Regeneració (Biologia)
Stem cells
Regeneration (Biology)
Issue Date: 2021
Publisher: MDPI
Abstract: Planarians are flatworms capable of whole-body regeneration, able to regrow any missing body part after injury or amputation. The extraordinary regenerative capacity of planarians is based upon the presence in the adult of a large population of somatic pluripotent stem cells. These cells, called neoblasts, offer a unique system to study the process of stem cell specification and differentiation in vivo. In recent years, FACS-based isolation of neoblasts, RNAi functional analyses as well as high-throughput approaches such as single-cell sequencing have allowed a rapid progress in our understanding of many different aspects of neoblast biology. Here, we summarize our current knowledge on the molecular signatures that define planarian neoblasts heterogeneity, which includes a percentage of truly pluripotent stem cells, and guide the commitment of pluripotent neoblasts into lineage-specific progenitor cells, as well as their differentiation into specific planarian cell types.
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It is part of: Biomolecules, 2021, vol. 11, num. 10, p. 1532
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ISSN: 2218-273X
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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