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Title: Naked mole rat TRF1 safeguards glycolytic capacity and telomere replication under low oxygen.
Author: Augereau, Adeline
Mariotti, Marco, 1984-
Pousse, Mélanie
Filipponi, Doria
Libert, Frédérick
Beck, Benjamin
Gorbunova, Vera
Gilson, Eric
Gladyshev, Vadim N.
Keywords: Rates
Issue Date: 1-Feb-2021
Publisher: American Association for the Advancement of Science
Abstract: The naked mole rat (NMR), a long-lived and cancer-resistant rodent, is highly resistant to hypoxia. Here, using robust cellular models wherein the mouse telomeric protein TRF1 is substituted by NMR TRF1 or its mutant forms, we show that TRF1 supports maximal glycolytic capacity under low oxygen, shows increased nuclear localization and association with telomeres, and protects telomeres from replicative stress. We pinpoint this evolutionary gain of metabolic function to specific amino acid changes in the homodimerization domain of this protein. We further find that NMR TRF1 accelerates telomere shortening. These findings reveal an evolutionary strategy to adapt telomere biology for metabolic control under an extreme environment.
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It is part of: Science Advances, 2021, vol. 7, num. 8
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ISSN: 2375-2548
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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