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https://hdl.handle.net/2445/195145| Title: | The Solid State Landscape of the Sildenafil Drug |
| Author: | Barbas Cañero, Rafael Llinàs, Antonio Prohens López, Rafael |
| Keywords: | Sildenafil Cristal·lització Polimorfisme (Cristal·lografia) Sildenafil Crystallization Polymorphism (Crystallography) |
| Issue Date: | Apr-2022 |
| Publisher: | Wiley |
| Abstract: | Sildenafil, the active ingredient of the drug developed by Pfizer for the treatment of erectile dysfunction was firstly synthesized in 1989 in the United Kingdom and since then it has become one of the most prescribed drugs for sexual performance in the western world with more than 2.7 million prescriptions in the US in 2021. Since its discovery, this drug compound has attracted the interest of formulators and crystallographers, with a high number of crystal forms of sildenafil being found and characterized, including polymorphs, hydrates, solvates, salts and cocrystals, converting it in one of the most promiscuous multicomponent crystal former drugs in the pharmaceutical sciences arena. In this minireview, the polymorph, pseudopolymorph and multicomponent solid forms landscape of sildenafil is presented through a comprehensive compilation of their 42 solid forms reported in literature |
| Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.xphs.2021.08.019 |
| It is part of: | Journal of Pharmaceutical Sciences, 2022, vol. 111, num. 4, p. 1104-1109 |
| URI: | https://hdl.handle.net/2445/195145 |
| Related resource: | https://doi.org/10.1016/j.xphs.2021.08.019 |
| ISSN: | 0022-3549 |
| Appears in Collections: | Articles publicats en revistes (Centres Científics i Tecnològics de la Universitat de Barcelona (CCiTUB)) |
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|---|---|---|---|---|
| 718211.pdf | 2.12 MB | Adobe PDF | View/Open |
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