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2021-06-01

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Thirty-day outcomes in frail older patients discharged home from the emergency department with acute heart failure: effects of high-risk criteria identified by the DEED FRAIL-AHF trial

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Objectives: To study the effect of high-risk criteria on 30-day outcomes in frail older patients with acute heart failure (AHF) discharged from an emergency department (ED) or an ED's observation and short-stay areas. Material and methods: Secondary analysis of discharge records in the Older AHF Key Data registry. We selected frail patients (aged > 70 years) discharged with AHF from EDs. Risk factors were categorized as modifiable or nonmodifiable. The outcomes were a composite endpoint for a cardiovascular event (revisits for AHF, hospitalization for AHF, or cardiovascular death) and the number of days alive out-of-hospital (DAOH) within 30 days of discharge. Results: We included 380 patients with a mean (SD) age of 86 (5.5) years (61.2% women). Modifiable risk factors were identified in 65.1%, nonmodifiable ones in 47.8%, and both types in 81.6%. The 30-day cardiovascular composite endpoint occurred in 83 patients (21.8%). The mean 30-day DAOH observed was 27.6 (6.1) days. Highrisk factors were present more often in patients who developed the cardiovascular event composite endpoint: the rates for patients with modifiable, nonmodifiable, or both types of risk were, respectively, as follows in comparison with patients not at high risk: 25.0% vs 17.2%, P = .092; 27.6% vs 16.7%, P = .010; and 24.7% vs 15.2%, P = .098). The 30-day DAOH outcome was also lower for at-risk patients, according to type of risk factor present: modifiable, 26.9 (7.0) vs 28.4 (4.4) days, P = .011; nonmodifiable, 27.1 (7.0) vs 28.0 (5.0) days, P = .127; and both, 27.1 (6.7) vs 28.8 (3.4) days, P = .005). After multivariate analysis, modifiable risk remained independently associated with fewer days alive (adjusted absolute difference in 30-day DAOH, -1.3 days (95% CI, -2.7 to -0.1 days). Nonmodifiable factors were associated with increased risk for the 30-day cardiovascular composite endpoint (adjusted absolute difference, 10.4%; 95% CI, -2.1% to 18.7%). Conclusion: Risk factors are common in frail elderly patients with AHF discharged home from hospital ED areas. Their presence is associated with a worse 30-day prognosis.

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Insuficiència cardíaca, Persones grans, Serveis d'urgències hospitalàries

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Heart failure, Older people, Hospital emergency services

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MARTÍN SÁNCHEZ, Francisco javier, PARRA ESQUIVEL, Patricia, LLOPIS GARCÍA, Guillermo, GONZÁLEZ DEL CASTILLO, Juan, RODRIGUEZ ADRADA, Esther, ESPINOSA, Begoña, LÓPEZ DIEZ, María pilar, ROMERO PAREJA, Rodolfo, RIZZI BORDIGONI, Miguel alberto, PÉREZ-DURÁ, María josé, BIBIANO, Carlos, FERRER, Carles, AGUILÓ, Sira, MARTÍN MOJARRO, Enrique, AGUIRRE TEJEDO, Alfons, PIÑERA, Pascual, LÓPEZ-PICADO, Amanda, LLORENS, Pere, JACOB, Javier, GIL, Víctor, HERRERO PUENTE, Pablo, FERNANDEZ PÉREZ, Cristina, GIL, Pedro, CALVO, Elpidio, ROSSELLO, Xavier, BUENO, Hector, BURILLO PUTZE, Guillermo, MIRÓ I ANDREU, Òscar. Thirty-day outcomes in frail older patients discharged home from the emergency department with acute heart failure: effects of high-risk criteria identified by the DEED FRAIL-AHF trial. _Emergencias_. 2021. Vol. 33, núm. 3, pàgs. 165-173. [consulta: 23 de gener de 2026]. ISSN: 1137-6821. [Disponible a: https://hdl.handle.net/2445/199507]

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