Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/201194
Title: | Microwave-Based Colonoscopy: Preclinical Evaluation in an Ex Vivo Human Colon Model |
Author: | Fernández Esparrach, Glòria Garrido, Alejandra Sont, Roberto Dghoughi, Walid Marcoval, Sergi Cuatrecasas Freixas, Miriam López-Prades, Sandra De Lacy, F. Borja Pellisé Urquiza, Maria Belda, Ignasi Guardiola, Marta |
Keywords: | Colonoscòpia Dispositius de microones Cirurgia colorectal Pòlips (Patologia) Tumors Colonoscopy Microwave devices Colorectal surgery Polyps (Pathology) Tumors |
Issue Date: | 28-Jan-2022 |
Publisher: | Hindawi |
Abstract: | Introduction: Microwave imaging can obtain 360° anatomical and functional images of the colon representing the existing contrast in dielectric properties between different tissues. Microwaves are safe (nonionizing) and have the potential of reducing the visualization problems of conventional colonoscopy. This study assessed the efficacy of a microwave-based colonoscopy device to detect neoplastic lesions in an ex vivo human colon model. Methods: Fresh surgically excised colorectal specimens containing cancer or polyps were fixed to a 3D positioning system, and the accessory device was introduced horizontally inside the ex vivo colon lumen and moved along it simulating a real colonoscopy exploration. Measurements of the colon were taken every 4 mm with the microwave-based colonoscopy device and processed with a microwave imaging algorithm. Results: 14 ex vivo human colorectal specimens with carcinomas (n = 11) or adenomas with high grade dysplasia (n = 3) were examined with a microwave-based device. Using a detection threshold of 2.79 for the dielectric property contrast, all lesions were detected without false positives or false negatives. Conclusions: This study demonstrates the use of a microwave-based device to be used as an accessory of a standard colonoscope to detect neoplastic lesions in surgically excised colorectal specimens. |
Note: | Reproducció del document publicat a: https://doi.org/10.1155/2022/9522737 |
It is part of: | Gastroenterology Research and Practice, 2022, vol. 2022, p. 9522737 |
URI: | http://hdl.handle.net/2445/201194 |
Related resource: | https://doi.org/10.1155/2022/9522737 |
ISSN: | 1687-6121 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Fonaments Clínics) |
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