Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/208098
Title: | High incidence of clinical fragility fractures in postmenopausal women with rheumatoid arthritis. A case-control study. |
Author: | Gómez Vaquero, Carmen Hernández, José Luis Olmos, José Manuel Cerdà, Dacia Hidalgo Calleja, Cristina Martínez López, Juan Antonio Arboleya, Luis Aguilar del Rey, Francisco Javier Martinez Pardo, Silvia Ros Vilamajó, Inmaculada Surís Grados, Dolors Beltrán Audera, Chesús Suero Rosario, Evelyn Gómez Gracia, Inmaculada Salmoral Chamizo, Asunción Martín Esteve, Irene Florez, Helena Naranjo, Antonio Castañeda, Santos Ojeda Bruno, Soledad García Carazo, Sara Garcia Vadillo, Alberto López Vives, Laura Martínez Ferrer, Àngels Borrell Paños, Helena Aguado Acín, Pilar Castellanos Moreira, Raúl Satorra Herbera, Pau Tebé, Cristian Guañabens Gay, Núria |
Keywords: | Menopausa Artritis reumatoide Fractures Osteoporosi Menopause Rheumatoid arthritis Fractures Osteoporosis |
Issue Date: | 1-Mar-2023 |
Publisher: | Elsevier B.V. |
Abstract: | Objectives: To estimate the incidence of clinical fragility fractures in postmenopausal women with rheumatoid arthritis (RA) and analyze risk factors for fracture. Methods: Incidence of clinical fragility fractures in 330 postmenopausal women with RA was compared to that of a control population of 660 age-matched postmenopausal Spanish women. Clinical fractures during the previous five years were recorded. We analyzed associations with risk factors for fracture in both populations and with disease-related variables in RA patients. Results: Median age of RA patients was 64 years; median RA duration was eight years. Sixty-nine percent were in remission or on low activity. Eighty-five percent had received glucocorticoids (GCs); 85 %, methotrexate; and 40 %, ≥1 biologic DMARD. Fifty-four patients and 47 controls had ≥1 major osteoporotic fracture (MOF). Incidence of MOFs was 3.55 per 100 patient-year in patients and 0.72 in controls (HR: 2.6). Risk factors for MOFs in RA patients were age, previous fracture, parental hip fracture, years since menopause, BMD, erosions, disease activity and disability, and cumulative dose of GCs. Previous fracture in RA patients was a strong risk for MOFs (HR: 10.37). Conclusion: Of every 100 postmenopausal Spanish women with RA, 3-4 have a MOF per year. This is more than double that of the general population. A previous fracture poses a high risk for a new fracture. Other classic risk factors for fracture, RA disease activity and disability, and the cumulative dose of GCs are associated with fracture development. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.bone.2022.116654 |
It is part of: | Bone, 2023 |
URI: | http://hdl.handle.net/2445/208098 |
Related resource: | https://doi.org/10.1016/j.bone.2022.116654 |
ISSN: | 8756-3282 |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
840311.pdf | 276.88 kB | Adobe PDF | View/Open |
This item is licensed under a
Creative Commons License