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https://hdl.handle.net/2445/221490
Títol: | Modular architecture facilitates noise-driven control of synchrony in neuronal networks |
Autor: | Yamamoto, Hideaki Spitzner, F. Paul Takemuro, Taiki Buendía, Victor Murota, Hakuba Morante, Carla Konno, Tomohiro Sato, Shigeo Hirano-Iwata, Ayumi Levina, Anna Priesemann, Viola Muñoz, Miguel A. Zierenberg, Johannes Soriano i Fradera, Jordi |
Matèria: | Xarxes neuronals (Informàtica) Mamífers Mètodes de simulació Neural networks (Computer science) Mammals Simulation methods |
Data de publicació: | 25-ago-2023 |
Publicat per: | American Association for the Advancement of Science |
Resum: | High-level information processing in the mammalian cortex requires both egregated processing in specialized circuits and integration across multiple circuits. One possible way to implement these seemingly opposing demands is by flexibly switching between states with different levels of synchrony. However, the mechanisms behind the control of complex synchronization patterns in neuronal networks remain elusive. Here, we use precision neuroengineering to manipulate and stimulate networks of cortical neurons in vitro, in combination with an in silico model of spiking neurons and a mesoscopic model of stochastically coupled modules to show that (i) a modular architecture enhances the sensitivity of the network to noise delivered as external asynchronous stimulation and that (ii) the persistent depletion of synaptic resources in stimulated neurons is the underlying mechanism for this effect. Together, our results demonstrate that the inherent dynamical state in structured networks of excitable units is determined by both its modular architecture and the properties of the external inputs. |
Nota: | Reproducció del document publicat a: https://doi.org/10.1126/sciadv.ade1755 |
És part de: | Science Advances, 2023, vol. 9, p. 1-12 |
URI: | https://hdl.handle.net/2445/221490 |
Recurs relacionat: | https://doi.org/10.1126/sciadv.ade1755 |
Apareix en les col·leccions: | Articles publicats en revistes (Física de la Matèria Condensada) Articles publicats en revistes (Institut de Recerca en Sistemes Complexos (UBICS)) |
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