Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/222241
Title: A new era in brain drug delivery: Integrating multivalency and computational optimisation for blood–brain barrier permeation
Author: Porro, Giulia Maria
Basile, Marco
Xie, Zhendong
Tuveri, Gianmarco
Battaglia, Giuseppe
Carvalho Ferreira Lopes, Cátia Daniela
Keywords: Neurofarmacologia
Farmacocinètica
Barrera hematoencefàlica
Neuropharmacology
Pharmacokinetics
Blood-brain barrier
Issue Date: 14-Jun-2025
Publisher: Elsevier
Abstract: Efficient drug delivery across the blood–brain barrier (BBB) remains a significant obstacle in treating central nervous system (CNS) disorders. This review provides an in-depth analysis of the structural and molecular mechanisms underlying BBB integrity and its functional properties. We detail the role of key cellular and molecular components that regulate selective molecular transport across the barrier, alongside a description of the current therapeutic approaches for brain drug delivery, including those leveraging receptor-mediated transcytosis. Emphasis is placed on multivalency-based strategies that enhance the specificity of nanoparticle targeting and improve transport efficacy across the BBB. Additionally, we discuss the added value of integrating mathematical and computational models with experimental validation for accelerating BBB-targeted delivery systems optimisation.
Note: Reproducció del document publicat a: https://doi.org/10.1016/j.addr.2025.115637
It is part of: Advanced Drug Delivery Reviews, 2025, vol. 224, 115637
URI: https://hdl.handle.net/2445/222241
Related resource: https://doi.org/10.1016/j.addr.2025.115637
ISSN: 0169-409X
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)
Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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