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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/223347
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dc.contributor.authorGhisoni, Eleonora-
dc.contributor.authorBenedetti, Fabrizio-
dc.contributor.authorMinasyan, Aspram-
dc.contributor.authorDesbuisson, Mathieu-
dc.contributor.authorCunnea, Paula-
dc.contributor.authorGrimm, Alizée J.-
dc.contributor.authorFahr, Noémie-
dc.contributor.authorCapt, Charlotte-
dc.contributor.authorRayroux, Nicolas-
dc.contributor.authorCarlo, Flavia de-
dc.contributor.authorGulhan, Doga C.-
dc.contributor.authorDagher, Julien-
dc.contributor.authorBarras, David-
dc.contributor.authorMorotti, Matteo-
dc.contributor.authorMarín Jiménez, Juan A.-
dc.contributor.authorStewen Chap, Bovannak-
dc.contributor.authorSantoro, Tania-
dc.contributor.authorSpagnol, Giulia-
dc.contributor.authorFleury, Mapi-
dc.contributor.authorFortis, Katerina-
dc.contributor.authorDorier, Julien-
dc.contributor.authorTownsend, Mary K.-
dc.contributor.authorTissot, Stephanie-
dc.contributor.authorRusakiewicz, Sylvie-
dc.contributor.authorFerreira, Humberto J.-
dc.contributor.authorKraemer, Anne I.-
dc.contributor.authorBassani Stenberg, Michal-
dc.contributor.authorSwisher, Elizabeth M.-
dc.contributor.authorKandalaft, Lana A.-
dc.contributor.authorMastroyannis, Spyridon A.-
dc.contributor.authorMontone, Kathleen T.-
dc.contributor.authorPowell, Daniel J.-
dc.contributor.authorBanerjee, Susana-
dc.contributor.authorTerry, Kathryn L.-
dc.contributor.authorTworoger, Shelley S.-
dc.contributor.authorPittet, Mikaël J.-
dc.contributor.authorTanyi, Janos L.-
dc.contributor.authorCoukos, George-
dc.contributor.authorMerritt, Melissa A.-
dc.contributor.authorFotopoulou, Christina-
dc.contributor.authorConejo García, José R.-
dc.contributor.authorDangaj Laniti, Denarda-
dc.date.accessioned2025-09-23T07:42:44Z-
dc.date.available2025-09-23T07:42:44Z-
dc.date.issued2025-07-31-
dc.identifier.issn1878-3686-
dc.identifier.urihttps://hdl.handle.net/2445/223347-
dc.description.abstractImmunotherapy has shown limited success in recurrent ovarian cancer (OC), with prognostic insights largely derived from treatment-naive tumors. We analyzed 697 tumor samples (566 primary and 131 recurrent) from 595 OC patients across five independent cohorts, capturing tumor-infiltrating lymphocytes (TILs) heterogeneity and identifying four immune phenotypes linked to prognosis and TIL:myeloid networks driving malignant progression. We found that in preclinical mouse models, mirroring inflamed human OCs, the recurrent Brca1mut tumors maintained activated TILs:dendritic cells (DCs) niches but evaded immune control through upregulation of COX/PGE2 signaling. Conversely, recurrent Brca1wt tumors displayed loss of TILs:DCs niches and accumulated immunosuppressive tumor microenvironment (TME) networks featuring Trem2/ ApoEhigh tumor associated macrophages (TAMs) and Nduf4l2high/Galectin3high malignant states. Recurrent tumors recapitulate the immunogenic landscapes of original cancers. Our findings reveal BRCA-dependent TIL:myeloid crosstalk as key to persistent immunogenicity in recurrent OC and propose new targets to enhance chemotherapy efficacy.-
dc.format.extent30 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherElsevier BV-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1016/j.ccell.2025.07.005-
dc.relation.ispartofCancer Cell, 2025, vol. 43, num. 8, p. 1568-1586-
dc.relation.urihttps://doi.org/10.1016/j.ccell.2025.07.005-
dc.rightscc-by (c) Ghisoni, Eleonora et al., 2025-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.sourceArticles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))-
dc.subject.classificationCàncer d'ovari-
dc.subject.classificationSistema immunitari-
dc.subject.otherOvarian cancer-
dc.subject.otherImmune system-
dc.titleMyeloid cell networks govern re-establishment of original immune landscapes in recurrent ovarian cancer-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.date.updated2025-09-22T10:08:31Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid40749672-
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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