Please use this identifier to cite or link to this item:
https://hdl.handle.net/2445/223810
Title: | Mediterranean Diet Modulates Gene Expression of Cholesterol Efflux Receptors in High-Risk Cardiovascular Patients |
Author: | Hernando Redondo, Javier Hernáez Camba, Álvaro Sanllorente, Albert Pintó Sala, Xavier Estruch Riba, Ramon Salas Salvadó, Jordi Corella Piquer, Dolores Arós, Fernando Martínez González, Miguel Ángel, 1957- Subirana Cachinero, Isaac Muñoz-Aguayo, Daniel Malcampo, Mireia Serra Majem, Lluís Romaguera, Dora Lapetra, José Ros Rahola, Emilio Tinahones, Francisco J. Lamuela Raventós, Rosa Ma. Gómez Gracia, Enrique Fitó Colomer, Montserrat Castañer, Olga |
Keywords: | Cuina mediterrània Dieta Malalties cardiovasculars Colesterol Mediterranean cooking Diet Cardiovascular diseases Cholesterol |
Issue Date: | 1-Jul-2025 |
Publisher: | Wiley-VCH |
Abstract: | In this study, we investigated gene expression related to cholesterol efflux receptors in individuals at high cardiovascular risk undergoing Mediterranean dietary interventions. Through transcriptomic analysis, we examined samples from two randomized controlled trials: PREDIMED and PREDIMED-Plus, with 151 and 89 elderly adults, respectively. Blood cells were isolated at baseline and after a 12-month intervention. In the PREDIMED trial, participants followed different Mediterranean diets: one supplemented with extra-virgin olive oil (traditional Mediterranean diet enriched with extra-virgin olive oil [MedDiet-EVOO]), another with nuts (MedDiet enriched with nuts MedDiet-Nuts [MedDiet-Nuts]), and a low-fat control diet. The PREDIMED-Plus trial compared an energy-reduced Mediterranean diet (Er-MedDiet) with physical activity to an ad libitum Mediterranean diet. Over time, mild but significant upregulation of genes like ATP binding cassette subfamily A member 1 (ABCA1), retinoid X receptor alpha (RXRA), retinoid X receptor beta (RXRB), and Nuclear Receptor Subfamily 1 Group H Member 3 (NR1H3) was observed in response to MedDiet-EVOO, MedDiet-Nuts, and Er-MedDiet. Notably, RXRA expression was higher in both MedDiet-EVOO and MedDiet-Nuts compared to the control diet. Differences in gene expression, particularly RXRA, ATP binding cassette subfamily G member 1 (ABCG1), NR1H3, and Peroxisome Proliferator Activated Receptor Delta (PPARD), were evident between MedDiet-Nuts and the control diet. In the PREDIMED-Plus trial, no significant differences in gene expression were found between dietary groups. Principal component analysis (PCA) and linear discriminant analysis (LDA) showed overlapping gene expression profiles across different Mediterranean diet interventions. In conclusion, our study highlights the cardiovascular health benefits of long-term adherence to a Mediterranean diet, both normocaloric and hypocaloric, primarily reflected by mild upregulation of cholesterol efflux-related genes-specifically involving RXRA, RXRB, ABCA1, ABCG1, Nuclear Receptor Subfamily 1 Group H Member 2(NR1H2), and PPARD-among elderly adults at high cardiovascular risk. This suggests a potential mechanism by which these diets may exert cardiovascular protective effects. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.70050 |
It is part of: | Molecular Nutrition & Food Research, 2025, vol. 69, num.13 |
URI: | https://hdl.handle.net/2445/223810 |
Related resource: | https://doi.org/10.1002/mnfr.70050 |
ISSN: | 1613-4125 |
Appears in Collections: | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
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