Amb motiu del tancament d'estiu, la validació de documents es reprendrà a partir del 28 d'agost de 2026. Disculpeu les molèsties.
Con motivo del cierre de verano, la validación de documentos se reanudará a partir del 28 de agosto de 2026. Disculpad las molestias
Due to the summer closure, document validation will resume starting August 28, 2026. We apologize for any inconvenience.

Fitxers

633710.pdf (927.73 KB)

Tipus de document

Article

Versió

Versió acceptada

Data de publicació

2014-02-05

Tots els drets reservats

Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/52728

Identification of metabolites and thermal transformation products of quinolones in raw cow milk by liquid chromatography coupled to high resolution mass spectrometry.

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.1021/jf405554z

Resum

The presence of residues of antibiotics, metabolites, and thermal transformation products (TPs), produced during thermal treatment to eliminate pathogenic microorganisms in milk, could represent a risk for people. Cow"s milk samples spiked with enrofloxacin (ENR), ciprofloxacin (CIP), difloxacin (DIF), and sarafloxacin (SAR) and milk samples from cows medicated with ENR were submitted to several thermal treatments. The milk samples were analyzed by liquid chromatography-mass spectrometry (LC-MS) to find and identify TPs and metabolites. In this work, 27 TPs of 4 quinolones and 24 metabolites of ENR were found. Some of these compounds had been reported previously, but others were characterized for the first time, including lactose-conjugated CIP, the formamidation reaction for CIP and SAR, and hydroxylation or ketone formation to produce three different isomers for all quinolones studied.

Matèries

Metabòlits, Quinolones, Llet, Cromatografia de líquids, Espectrometria de masses, Antibiòtics, Tractament tèrmic

Matèries (anglès)

Metabolites, Quinolone antibacterial agents, Milk, Liquid chromatography, Mass spectrometry, Antibiotics, Heat treatment

Citació

Col·leccions

Articles publicats en revistes (Enginyeria Química i Química Analítica)

Citació

JUNZA MARTÍNEZ, Alexandra, et al. Identification of metabolites and thermal transformation products of quinolones in raw cow milk by liquid chromatography coupled to high resolution mass spectrometry. Journal of Agricultural and Food Chemistry. 2014. Vol. 62, num. 8, pags. 2008-2021. ISSN 0021-8561. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/52728

Exportar metadades

JSON - METS

Compartir registre