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Title: | Noradrenergic stimulation enhances human action monitoring |
Author: | Riba, Jordi Rodríguez Fornells, Antoni Morte, Adelaida Münte, Thomas F. Barbanoj, Manel J. |
Keywords: | Potencials evocats (Electrofisiologia) Escorça cerebral Catecolamines Conducta (Psicologia) Evoked potentials (Electrophysiology) Cerebral cortex Catecholamines Human behavior |
Issue Date: | 2005 |
Publisher: | The Society for Neuroscience |
Abstract: | Noradrenergic neurotransmission has been associated with the modulation of higher cognitive functions mediated by the prefrontal cortex. In the present study, the impact of noradrenergic stimulation on the human action-monitoring system, as indexed by eventrelated brain potentials, was examined. After the administration of a placebo or the selective 2 -adrenoceptor antagonist yohimbine, which stimulates firing in the locus ceruleus and noradrenaline release, electroencephalograpic recordings were obtained from healthy volunteers performing a letter flanker task. Yohimbine led to an increase in the amplitude of the error-related negativity in conjunction with a significant reduction of action errors. Reaction times were unchanged, and the drug did not modify the N2 in congruent versus incongruent trials, a measure of preresponse conflict, or posterror adjustments as measured by posterror slowing of reaction time. The present findings suggest that the locus ceruleus<br>noradrenaline system exerts a rather specific effect on human action monitoring. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1523/JNEUROSCI.4437-04.2005 |
It is part of: | Journal of Neuroscience, 2005, vol. 25, num. 17, p. 4370-4374 |
URI: | http://hdl.handle.net/2445/65265 |
Related resource: | http://dx.doi.org/10.1523/JNEUROSCI.4437-04.2005 |
ISSN: | 0270-6474 |
Appears in Collections: | Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) |
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