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2026-01-01

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cc-by-nc-nd (c) Montagud-Marrahi, E. et al., 2026
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/230910

Quality Assessment of Discarded Human Kidneys Using Normothermic Perfusion

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Background. Ex vivo normothermic perfusion (EVNP) allows for comprehensive functional assessment; however, current scoring systems are validated only for short perfusion durations. This study investigates the utility of the EVNP quality assessment score for a 6-h period to predict viability in discarded human kidneys. Methods. Twenty human kidneys from marginal donors, previously declined for transplantation, underwent 6-h EVNP. Functional parameters (renal blood flow, resistance index, urine output), perfusate biochemistry, tissue injury biomarkers, and histology were assessed. Kidneys were stratified by EVNP score: group A (1–2), group B (3), and group C (4–5). Results. Group A demonstrated significantly higher renal blood flow (median 213.5 versus 145.1 [B] versus 81.7 mL/min [C], P < 0.0001), lower resistance index (0.32 versus 0.41 [B] versus 0.86 mL/min/mm Hg [C], P < 0.0001), greater urine output (241.1 versus 97.9 [B] versus 10.9 mL [C], P < 0.0001), and more favorable perfusate profiles (lactate: 14.2 versus 15.7 [B] versus 19.9 mg/dL [C], P = 0.02). Histological scores did not correlate with EVNP score groups at baseline or after perfusion. EVNP during 6 h showed trends consistent with functional graft performance, suggesting it may help inform decisions to reduce organ discard. Conclusions. The EVNP score may assist in identifying kidneys with potential for transplantation despite suboptimal histology, which could contribute to reducing the underutilization of marginal grafts.

Recurs relacionat

https://doi.org/10.1097/TXD.0000000000001884

Matèries

Trasplantament renal, Perfusió (Fisiologia)

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Kidney transplantation, Perfusion (Physiology)

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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MONTAGUD MARRAHI, Enrique, et al. Quality Assessment of Discarded Human Kidneys Using Normothermic Perfusion. Transplantation Direct. 2026. Vol. 12, num. 1, pags. e1884. ISSN 2373-8731. [consulted: 11 of November of 2026]. Available at: https://hdl.handle.net/2445/230910

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