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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/123114
Lipophilicity determination of acidic compounds: MEEKC as a reliable high-throughput methodology
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In the present study apressure-assisted MEEKC method with reversed-polarity using a conventional CE instrument with UV detection and uncoated fused silica capillariesis validated as a high-throughput methodology for the lipophilicity determination of the neutral species of acidic compounds(pKa> 3.5).After the calibration of the system with four standard compoundsof known log Po/w, mass distribution ratios (log kMEEKC) of new molecules can be directly converted into log Po/wvalues by means of a simple linear equation (log Po/w=a·log kMEEKC+b). The method was internally and externally validated for a log Po/wrange between-1.54 and4.75, with higheraccuraciesthan conventional liquid chromatographic methods.
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SUBIRATS I VILA, Xavier, REDÓN, Lídia and ROSÉS PASCUAL, Martí. Lipophilicity determination of acidic compounds: MEEKC as a reliable high-throughput methodology. ADMET & DMPK. 2018. Vol. 6, num. 2, pags. 153-161. ISSN 1848-7718. [consulted: 15 of August of 2026]. Available at: https://hdl.handle.net/2445/123114