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2015-05-27

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cc-by (c) Herms, Albert et al., 2015
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/118508

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

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https://doi.org/10.1038/ncomms8176

Abstract

Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and whether it facilitates interaction with other organelles are unclear. Here we show that during nutrient starvation, LDs and mitochondria relocate on detyrosinated MT from the cell centre to adopt a dispersed distribution. In the cell periphery, LD-mitochondria interactions increase and LDs efficiently supply FAs for mitochondrial beta-oxidation. This cellular adaptation requires the activation of the energy sensor AMPK, which in response to starvation simultaneously increases LD motion, reorganizes the network of detyrosinated MTs and activates mitochondria. In conclusion, we describe the existence of a specialized cellular network connecting the cellular energetic status and MT dynamics to coordinate the functioning of LDs and mitochondria during nutrient scarcity.

Subject

Metabolisme dels lípids, Transport biològic, Mitocondris, Microtúbuls

Subject (English)

Lipid metabolism, Biological transport, Mitochondria, Microtubules

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Articles publicats en revistes (Biomedicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

Citation

HERMS FIOL, Albert, et al. AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation. Nature Communications. 2015. Vol. 6, num. 7176. ISSN 2041-1723. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/118508

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