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Publication date

2021-04-27

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cc-by (c) Melo Vallès, Ada et al., 2021
Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/195341

Review of the Microbiological Diagnostic Approaches of COVID-19

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https://doi.org/10.3389/fpubh.2021.592500

Abstract

On March 12, the World Health Organization declared a pandemic following the exponential increase of SARS-CoV-2 cases. The rapid spread of the virus is due to both its high infectivity and the free circulation of unrecognized infectious cases. Thus, diagnostic testing is a key element to prevent further dissemination of the virus. Urged by WHO's call, laboratories worldwide have been working on nucleic acid tests protocols and immunoassays that became available, albeit poorly validated, within a comparatively short time. Since then, external studies evaluating these diagnostic tests have been published. The present study is a review of the COVID-19 diagnostic approaches, discussing both direct and indirect microbiological diagnoses. A compendium of the literature on commercial assays kits available to date is provided together with the conclusions drawn as well as RT-PCR protocols published by the WHO. Briefly, diagnostic accuracy varies according to time elapsed since symptom onset and evolves together with understanding of the COVID-19 disease. Taking into account all these variables will allow determining the most adequate diagnostic test to use and how to optimize diagnostic testing for COVID-19.

Subject

SARS-CoV-2, COVID-19, Diagnòstic microbiològic, Tests de sensibilitat microbiològica, Interdisciplinarietat

Subject (English)

SARS-CoV-2, COVID-19, Diagnostic microbiology, Microbial sensitivity tests, Interdisciplinary approach to knowledge

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Articles publicats en revistes (Fonaments Clínics)
Articles publicats en revistes (ISGlobal)

Citation

MELO VALLÈS, Ada, BALLESTÉ DELPIERRE, Clara Celia and VILA ESTAPÉ, Jordi. Review of the Microbiological Diagnostic Approaches of COVID-19. Frontiers In Public Health. 2021. Vol. 9, num. 592500. ISSN 2296-2565. [consulted: 12 of August of 2026]. Available at: https://hdl.handle.net/2445/195341

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