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2019-12-23

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cc-by (c) Palomo-Guerrero, Marta et al., 2019
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/152738

Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth

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Recurs relacionat

https://doi.org/10.7554/eLife.51063

Resum

Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored. Malonyl-CoA is a precursor of fatty acids, and its intracellular levels highly fluctuate depending on glucose availability or the energy sensor AMP-activated protein kinase (AMPK). We demonstrate in HeLa cells that carnitine palmitoyltransferase 1C (CPT1C) senses malonyl-CoA and enhances LE/Lys anterograde transport by interacting with the endoplasmic reticulum protein protrudin and facilitating the transfer of Kinesin-1 from protrudin to LE/Lys. In cultured mouse cortical neurons, glucose deprivation, pharmacological activation of AMPK or inhibition of malonyl-CoA synthesis decreases LE/Lys abundance at the axon terminal, and shortens axon length in a CPT1C-dependent manner. These results identify CPT1C as a new regulator of anterograde LE/Lys transport in response to malonyl-CoA changes, and give insight into how axon growth is controlled by nutrients.

Matèries

Carnitina palmitoïl-transferasa 1, Axons, Lisosomes

Matèries (anglès)

Carnitine palmitoyltransferase I, Axons, Lysosomes

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Articles publicats en revistes (Bioquímica i Fisiologia)

Citació

PALOMO-GUERRERO, Marta, et al. Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth. eLife. 2019. Vol. 8, num. e51063. ISSN 2050-084X. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/152738

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