Miniatura

Fitxers

658384.pdf (1.99 MB)

Tipus de document

Article

Versió

Versió publicada

Data de publicació

2015-10-22

Llicència de publicació

cc-by-nc-nd (c) Faria, M. et al., 2015
Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/99680

Zebrafish models for human acute organophosphorus poisoning

Títol de la revista

Autors

Director/Tutor

ISSN de la revista

Títol del volum

Recurs relacionat

http://dx.doi.org/10.1038/srep15591

Resum

Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syrian civil war. Thus, development of more effective countermeasures against acute organophosphorus poisoning is urgently needed. Here, we have generated and validated zebrafish models for mild, moderate and severe acute organophosphorus poisoning by exposing zebrafish larvae to different concentrations of the prototypic organophosphorus compound chlorpyrifos-oxon. Our results show that zebrafish models mimic most of the pathophysiological mechanisms behind this toxidrome in humans, including acetylcholinesterase inhibition, N-methyl-D-aspartate receptor activation, and calcium dysregulation as well as inflammatory and immune responses. The suitability of the zebrafish larvae to in vivo high-throughput screenings of small molecule libraries makes these models a valuable tool for identifying new drugs for multifunctional drug therapy against acute organophosphorus poisoning.

Matèries

Toxicologia, Armes químiques

Matèries (anglès)

Toxicology, Chemical weapons

Citació

Col·leccions

Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
<b>Publicacions de projectes de recerca finançats per la UE</b>
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

Citació

FARIA, Melissa, GARCIA-REYERO, Natàlia, PADRÓS, Francesc, BABIN, Patrick j., SEBASTIÁN MUÑOZ, David, CACHOT, Jérôme, PRATS, Eva, ARICK II, Mark, RIAL, Eduardo, KNOLL-GELLIDA, Anja, MATHIEU, Guilaine, LE BIHANIC, Florane, ESCALON, B. lynn, ZORZANO OLARTE, Antonio, SOARES, Amadeu m. v. m., RALDÚA, Demetrio. Zebrafish models for human acute organophosphorus poisoning. _Scientific Reports_. 2015. Vol. 5, núm. 15591. [consulta: 20 de gener de 2026]. ISSN: 2045-2322. [Disponible a: https://hdl.handle.net/2445/99680]

Exportar metadades

JSON - METS

Compartir registre