Evaluation of logPo/w values of drugs from some molecular structure calculation software

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dc.contributor.authorPallicer Santana, Juan Manuel
dc.contributor.authorRosés Pascual, Martí
dc.contributor.authorRàfols Llach, Clara
dc.contributor.authorBosch, Elisabeth
dc.contributor.authorPascual, Rosalía
dc.contributor.authorPort, Ariadna
dc.date.accessioned2019-10-28T17:49:39Z
dc.date.available2019-10-28T17:49:39Z
dc.date.issued2014
dc.date.updated2019-10-28T17:49:39Z
dc.description.abstractThe iridium‐catalyzed asymmetric hydrogenation of several N‐sulfonyl allyl amines is reported. All substrates can be easily obtained by the Ir‐catalyzed isomerization of N‐tosylaziridines reported previously. The commercially available threonine‐derived phosphinite (UbaPHOX) iridium complex has been found to be the best catalyst for this catalytic application, affording β‐methyl amines with good to excellent ee values (up to 94%). The synthetic potential of this novel methodology was demonstrated by the formal synthesis of Lorcaserin and LY‐404187.
dc.format.extent8 p.
dc.format.mimetypeapplication/pdf
dc.identifier.idgrec643435
dc.identifier.issn1848-7718
dc.identifier.urihttps://hdl.handle.net/2445/143378
dc.language.isoeng
dc.publisherIAPC Publishing
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.5599/admet.2.2.45
dc.relation.ispartofADMET & DMPK, 2014, vol. 2, num. 2, p. 107-114
dc.relation.urihttps://doi.org/10.5599/admet.2.2.45
dc.rightscc-by (c) Pallicer Santana, Juan Manuel et al., 2014
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es
dc.sourceArticles publicats en revistes (Enginyeria Química i Química Analítica)
dc.subject.classificationLipofília
dc.subject.classificationQuímica farmacèutica
dc.subject.otherLipophilicity
dc.subject.otherPharmaceutical chemistry
dc.titleEvaluation of logPo/w values of drugs from some molecular structure calculation software
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion

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