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Si us plau utilitzeu sempre aquest identificador per citar o enllaçar aquest document: https://hdl.handle.net/2445/192167
Dynamic and functional alterations of neuronal networks in vitro upon physical damage: a proof of concept
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There is a growing technological interest in combining biological neuronal networks with electronic ones, specifically for biological computation, human-machine interfacing and robotic implants. A major challenge for the development of these technologies is the resilience of the biological networks to physical damage, for instance, when used in harsh environments. To tackle this question, here, we investigated the dynamic and functional alterations of rodent cortical networks grown in vitro that were physically damaged, either by sequentially removing groups of neurons that were central for information flow or by applying an incision that cut the network in half. In both cases, we observed a remarkable capacity of the neuronal cultures to cope with damage, maintaining their activity and even reestablishing lost communication pathways. We also observed¿particularly for the cultures cut in half¿that a reservoir of healthy neurons surrounding the damaged region could boost resilience by providing stimulation and a communication bridge across disconnected areas. Our results show the remarkable capacity of neuronal cultures to sustain and recover from damage, and may be inspirational for the development of future hybrid biological-electronic systems.
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Sàlem Ayasreh, Imanol Jurado, Clara F. López León, Marc Montalà Flaquer, Jordi Soriano i Fradera. Dynamic and functional alterations of neuronal networks in vitro upon physical damage: a proof of concept. _Micromachines_. 2022. Vol. 13, núm. 12, pàgs. 2259. [consulta: 21 de gener de 2026]. ISSN: 2072-666X. [Disponible a: https://hdl.handle.net/2445/192167]