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Article

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Accepted version

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2018-03

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Please use this identifier to cite or link to this item: https://hdl.handle.net/2445/166221

Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats

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https://doi.org/10.1017/S0007114517003786

Abstract

At birth, when immune responses are insufficient, there begins the development of the defence capability against pathogens. Leptin and adiponectin, adipokines that are present in breast milk, have been shown to play a role in the regulation of immune responses. We report here, for the first time, the influence of in vivo adipokine supplementation on the intestinal immune system in early life. Suckling Wistar rats were daily supplemented with leptin (0·7 μg/kg per d, n 36) or adiponectin (35 μg/kg per d, n 36) during the suckling period. The lymphocyte composition,proliferation and cytokine secretion from mesenteric lymph node lymphocytes (on days 14 and 21), as well as intestinal IgA and IgM concentration (day 21), were evaluated. At day 14, leptin supplementation significantly increased the TCRαβ+ cell proportion in mesenteric lymph nodes, in particular owing to an increase in the TCRαβ+ CD8+ cell population. Moreover, the leptin or adiponectin supplementation promoted the early development CD8+ cells, with adiponectin being the only adipokine capable of enhancing the lymphoproliferative ability at the end of the suckling period. Although leptin decreased intestinal IgA concentration, it had a trophic effect on the intestine in early life. Supplementation of both adipokines modulated the cytokine profile during (day 14) and at the end (day 21) of the suckling period. These results suggest that leptin and adiponectin during suckling play a role in the development of mucosal immunity in early life.

Subject

Farmacologia, Immunologia, Suplements nutritius, Llet materna, Rates (Animals de laboratori)

Subject (English)

Pharmacology, Immunology, Dietary supplements, Breast milk, Rats as laboratory animals

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Articles publicats en revistes (Bioquímica i Fisiologia)

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GRASES PINTÓ, Blanca, et al. Leptin and adiponectin supplementation modifies mesenteric lymph node lymphocyte composition and functionality in suckling rats. British Journal of Nutrition. 2018. Vol. 119, num. 5, pags. 486-495. ISSN 0007-1145. [consulted: 8 of August of 2026]. Available at: https://hdl.handle.net/2445/166221

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